Study of Antiviral Diclofenac by Surface-Enhanced Raman Spectroscopy

Diclofenac is a medication that presents in its structure two benzene rings joined by an amine group presenting: The first ring two chlorine atoms, both in the ortho position with respect to the amino group and the second ring is bound to ethanoic acid, also in ortho position with respect to this amino group, thus showing the carboxylate group (COO-). We have studied the Raman spectrum of solid Diclofenac (DCF), their spectra in solution in methanol at different concentrations and Surface-Enhanced Raman Spectroscopy (SERS) with additives that increase the profile of spectra. The interaction of this molecule with Ag (that is in the colloid used in SERS), is significant on the two rings, the COO- and amine group and Cl atom and C7H2 group, everyone in the structure of DCF.