J. Kozempel, M. Hrubý, M. Nováková, J. Kučka, L. Lešetický, O. Lebeda
{"title":"新型64Cu聚合物载体","authors":"J. Kozempel, M. Hrubý, M. Nováková, J. Kučka, L. Lešetický, O. Lebeda","doi":"10.1524/RACT.2009.1669","DOIUrl":null,"url":null,"abstract":"Abstract We describe a preparation of novel polymer vectors of 64Cu based on co-polymers of poly- (N-isopropylacrylamide) and poly- (N-hydroxypropylmethacrylamide). DOTA, DTPA, dipicolylamine, thiosemicarbazone and Ag-ionophore-II ligands were tested to bind 64Cu in a polymer chain. Labeling yields with no-carrier-added 64Cu varied from 95 to 99% in 30 min. at laboratory temperature. Vectors were stable in vitro for 24 h in human serum and might be prospective for targeted 64Cu radio or combined radiochemotherapy.","PeriodicalId":21029,"journal":{"name":"Radiochimica Acta Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Novel polymer vectors of 64Cu\",\"authors\":\"J. Kozempel, M. Hrubý, M. Nováková, J. Kučka, L. Lešetický, O. Lebeda\",\"doi\":\"10.1524/RACT.2009.1669\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract We describe a preparation of novel polymer vectors of 64Cu based on co-polymers of poly- (N-isopropylacrylamide) and poly- (N-hydroxypropylmethacrylamide). DOTA, DTPA, dipicolylamine, thiosemicarbazone and Ag-ionophore-II ligands were tested to bind 64Cu in a polymer chain. Labeling yields with no-carrier-added 64Cu varied from 95 to 99% in 30 min. at laboratory temperature. Vectors were stable in vitro for 24 h in human serum and might be prospective for targeted 64Cu radio or combined radiochemotherapy.\",\"PeriodicalId\":21029,\"journal\":{\"name\":\"Radiochimica Acta Radiochimica Acta\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Radiochimica Acta Radiochimica Acta\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1524/RACT.2009.1669\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiochimica Acta Radiochimica Acta","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1524/RACT.2009.1669","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Abstract We describe a preparation of novel polymer vectors of 64Cu based on co-polymers of poly- (N-isopropylacrylamide) and poly- (N-hydroxypropylmethacrylamide). DOTA, DTPA, dipicolylamine, thiosemicarbazone and Ag-ionophore-II ligands were tested to bind 64Cu in a polymer chain. Labeling yields with no-carrier-added 64Cu varied from 95 to 99% in 30 min. at laboratory temperature. Vectors were stable in vitro for 24 h in human serum and might be prospective for targeted 64Cu radio or combined radiochemotherapy.
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