{"title":"膳食补充DL‐α‐硫辛酸对老年大鼠脑过氧化抗氧化状态的影响","authors":"P. Arivazhagan, C. Panneerselvam","doi":"10.1211/146080800128736114","DOIUrl":null,"url":null,"abstract":"The effects of dietary DL-α-lipoic acid supplementation on lipid peroxidation and antioxidant status have been evaluated in the brain of young and aged rats. \n \n \n \nIn aged rats, antioxidant status was low whereas levels of thiobarbituric acid-reactive substances were high. Intraperitoneal administration of DL-α-lipoic acid to experimental rats at 100 mgkg−1 day−1 for 7 and 14 days resulted in a duration-dependent reduction in lipid peroxidation and an elevation in the levels and activity of antioxidants. \n \n \n \nDL-α-Lipoic acid supplementation can increase the activity of brain antioxidants during ageing and minimize free radical-induced age-associated disorders in the brain.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Effect of Dietary DL‐α‐Lipoic Acid Supplementation on Peroxidative Antioxidant Status in the Brain of Aged Rats\",\"authors\":\"P. Arivazhagan, C. Panneerselvam\",\"doi\":\"10.1211/146080800128736114\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The effects of dietary DL-α-lipoic acid supplementation on lipid peroxidation and antioxidant status have been evaluated in the brain of young and aged rats. \\n \\n \\n \\nIn aged rats, antioxidant status was low whereas levels of thiobarbituric acid-reactive substances were high. Intraperitoneal administration of DL-α-lipoic acid to experimental rats at 100 mgkg−1 day−1 for 7 and 14 days resulted in a duration-dependent reduction in lipid peroxidation and an elevation in the levels and activity of antioxidants. \\n \\n \\n \\nDL-α-Lipoic acid supplementation can increase the activity of brain antioxidants during ageing and minimize free radical-induced age-associated disorders in the brain.\",\"PeriodicalId\":19946,\"journal\":{\"name\":\"Pharmacy and Pharmacology Communications\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacy and Pharmacology Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1211/146080800128736114\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacy and Pharmacology Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1211/146080800128736114","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of Dietary DL‐α‐Lipoic Acid Supplementation on Peroxidative Antioxidant Status in the Brain of Aged Rats
The effects of dietary DL-α-lipoic acid supplementation on lipid peroxidation and antioxidant status have been evaluated in the brain of young and aged rats.
In aged rats, antioxidant status was low whereas levels of thiobarbituric acid-reactive substances were high. Intraperitoneal administration of DL-α-lipoic acid to experimental rats at 100 mgkg−1 day−1 for 7 and 14 days resulted in a duration-dependent reduction in lipid peroxidation and an elevation in the levels and activity of antioxidants.
DL-α-Lipoic acid supplementation can increase the activity of brain antioxidants during ageing and minimize free radical-induced age-associated disorders in the brain.
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