021发射UVB的光纤发刷,用于治疗头皮牛皮癣

A. Taneja, M. Trehan, S. Gupta, A. Racette, S. Regan, Zafirios Gourgouliatos, C. R. Taylor
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引用次数: 0

摘要

这项正在进行的工作评估了一种独特的UVB光纤梳装置治疗头皮牛皮癣的功效。11名入组患者获得了知情同意。留下一个头皮银屑病斑块作为对照,而另一个被选中进行治疗。在下背部或臀部皮肤上进行MED以确定受试者对梳状装置的基线敏感性。在选定的位置上,矿物油首先与浸透的纱布一起涂抹,以增强紫外线的传递,第一次治疗是1 MED。随后的治疗是每周三次,间隔72小时,每次治疗的最大增量为20%。治疗在12周后或清除出现时结束,以先到者为准。在基线和之后每2周进行临床评估和标准化照片拍摄。结果患者平均接受24次治疗(范围2 ~ 36次)。在基线时,治疗组和对照组的PASI评分无显著差异(平均差异:0.4,P= 0.1106)。改善评分,通过从基线值减去最近的PASI评分计算,治疗侧更高(3.9比0.3,P = 0.0002)。3例患者的对照区出现恶化。11例患者中有10例治疗部位出现改善;没有人出现症状恶化。结论光纤刷在治疗头皮银屑病方面具有广阔的应用前景。
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021 UVB emitting fiber optic hair brush for the treatment of scalp psoriasis
This work-in-progress evaluates the efficacy of a unique UVB fiber optic comb device for treating scalp psoriasis. Informed consent was obtained on 11 enrolled patients. One scalp psoriasis plaque was left as a control, while another was selected for treatment. An MED was performed on the lower back or gluteal skin to determine the subject's baseline sensitivity to the comb device. On the selected sit, mineral oil was first applied with a soaked gauze to enhance UV delivery and the first treatment was at 1 MED. Subsequent treatments were thrice weekly at 72 h intervals with maximum increments of 20% per treatment. Treatments ended after 12 weeks or when clearing occurred, whichever came first. Clinical evaluation and standardized photographs were taken at baseline and every 2 weeks thereafter. Results  On average, patients have received 24 treatments (range: 2–36). At baseline, PASI scores for the treated and control sides did not differ significantly (mean difference: 0.4, P= 0.1106). Improvement scores, calculated by subtracting the most recent PASI score from the baseline value, were higher for the treated sides (3.9 vs. 0.3, P = 0.0002). Three patients showed worsening in the control area. Ten of the 11 patients showed improvement in the treated area; none experienced worsening of symptoms. Conclusions  The fiber optic brush offers an exciting potential for treating scalp psoriasis.
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