{"title":"乙炔雌二醇对雄性大鼠肝细胞质膜脂质和蛋白质横向迁移的影响(肝涂片FRAP研究)","authors":"Kenichi Kitani, Imre Zs.-Nagy","doi":"10.1016/0928-4346(96)00303-9","DOIUrl":null,"url":null,"abstract":"<div><p>The lateral diffusion constants of lipids (D<sub>1</sub>) and proteins (D<sub>p</sub>) in the plasma membranes of hepatocytes were measured in liver smears of male Fischer 344 rats, by means of the fluorescence recovery after photobleaching (FRAP) method, after ethinyl-estradiol (EE) treatment of 1 or 5 days. The main finding was that EE treatment results in significant decreases in both the D<sub>1</sub>- and the D<sub>p</sub>-values. These observations are interpreted in terms of the role of membrane physicochemistry in functions of the hepatocytes.</p></div>","PeriodicalId":13746,"journal":{"name":"International Hepatology Communications","volume":"5 4","pages":"Pages 236-243"},"PeriodicalIF":0.0000,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0928-4346(96)00303-9","citationCount":"7","resultStr":"{\"title\":\"The effect of ethinyl-estradiol treatment on the lateral mobility of lipids and proteins in hepatocyte plasma membrane of male rats (FRAP studies on liver smears)\",\"authors\":\"Kenichi Kitani, Imre Zs.-Nagy\",\"doi\":\"10.1016/0928-4346(96)00303-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The lateral diffusion constants of lipids (D<sub>1</sub>) and proteins (D<sub>p</sub>) in the plasma membranes of hepatocytes were measured in liver smears of male Fischer 344 rats, by means of the fluorescence recovery after photobleaching (FRAP) method, after ethinyl-estradiol (EE) treatment of 1 or 5 days. The main finding was that EE treatment results in significant decreases in both the D<sub>1</sub>- and the D<sub>p</sub>-values. These observations are interpreted in terms of the role of membrane physicochemistry in functions of the hepatocytes.</p></div>\",\"PeriodicalId\":13746,\"journal\":{\"name\":\"International Hepatology Communications\",\"volume\":\"5 4\",\"pages\":\"Pages 236-243\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0928-4346(96)00303-9\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Hepatology Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0928434696003039\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Hepatology Communications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0928434696003039","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effect of ethinyl-estradiol treatment on the lateral mobility of lipids and proteins in hepatocyte plasma membrane of male rats (FRAP studies on liver smears)
The lateral diffusion constants of lipids (D1) and proteins (Dp) in the plasma membranes of hepatocytes were measured in liver smears of male Fischer 344 rats, by means of the fluorescence recovery after photobleaching (FRAP) method, after ethinyl-estradiol (EE) treatment of 1 or 5 days. The main finding was that EE treatment results in significant decreases in both the D1- and the Dp-values. These observations are interpreted in terms of the role of membrane physicochemistry in functions of the hepatocytes.
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