{"title":"内毒素敏感和耐药C3H小鼠的遗传差异","authors":"L.G. Gurtler , W.R. Rank","doi":"10.1016/S0340-904X(76)80026-7","DOIUrl":null,"url":null,"abstract":"<div><p>The 2 related mouse strains C3H/HeJ and C3H/Han differ in their response to endotoxin. C3H/HeJ mice are endotoxin-resistant, C3H/Han mice are - like all other mice - endotoxin-sensitive. The uptake of fluorescent intraperitoneally injected lipopolysaccharide was similar in both mouse strains. The intraperitoneal injection of lipopolysaccharide produced a higher mobilization of neutrophil granulocytes in resistant C3H/HeJ mice than in C3H/Han mice. An opposite pattern of mobilization of neutrophil granulocytes could be observed after injection of the prostaglandins E 1, E 2, and F 1 α; when both mouse strains were compared, a normal mobilization was observed in C3H/Han mice C3H/HeJ mice showed a markedly decreased mobilization.</p><p>If the difference between the 2 strains resides in a single gene locus it is to be assumed that lipopolysaccharide resistance is controlled by the same gene which also effects an impaired response to neutrophil mobilization after prostaglandin application.</p></div>","PeriodicalId":101289,"journal":{"name":"Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie","volume":"151 5","pages":"Pages 420-429"},"PeriodicalIF":0.0000,"publicationDate":"1976-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0340-904X(76)80026-7","citationCount":"3","resultStr":"{\"title\":\"Genetic Differences Between Endotoxin-Sensitive and Resistant C3H Mice\",\"authors\":\"L.G. Gurtler , W.R. Rank\",\"doi\":\"10.1016/S0340-904X(76)80026-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The 2 related mouse strains C3H/HeJ and C3H/Han differ in their response to endotoxin. C3H/HeJ mice are endotoxin-resistant, C3H/Han mice are - like all other mice - endotoxin-sensitive. The uptake of fluorescent intraperitoneally injected lipopolysaccharide was similar in both mouse strains. The intraperitoneal injection of lipopolysaccharide produced a higher mobilization of neutrophil granulocytes in resistant C3H/HeJ mice than in C3H/Han mice. An opposite pattern of mobilization of neutrophil granulocytes could be observed after injection of the prostaglandins E 1, E 2, and F 1 α; when both mouse strains were compared, a normal mobilization was observed in C3H/Han mice C3H/HeJ mice showed a markedly decreased mobilization.</p><p>If the difference between the 2 strains resides in a single gene locus it is to be assumed that lipopolysaccharide resistance is controlled by the same gene which also effects an impaired response to neutrophil mobilization after prostaglandin application.</p></div>\",\"PeriodicalId\":101289,\"journal\":{\"name\":\"Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie\",\"volume\":\"151 5\",\"pages\":\"Pages 420-429\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1976-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0340-904X(76)80026-7\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0340904X76800267\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0340904X76800267","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Genetic Differences Between Endotoxin-Sensitive and Resistant C3H Mice
The 2 related mouse strains C3H/HeJ and C3H/Han differ in their response to endotoxin. C3H/HeJ mice are endotoxin-resistant, C3H/Han mice are - like all other mice - endotoxin-sensitive. The uptake of fluorescent intraperitoneally injected lipopolysaccharide was similar in both mouse strains. The intraperitoneal injection of lipopolysaccharide produced a higher mobilization of neutrophil granulocytes in resistant C3H/HeJ mice than in C3H/Han mice. An opposite pattern of mobilization of neutrophil granulocytes could be observed after injection of the prostaglandins E 1, E 2, and F 1 α; when both mouse strains were compared, a normal mobilization was observed in C3H/Han mice C3H/HeJ mice showed a markedly decreased mobilization.
If the difference between the 2 strains resides in a single gene locus it is to be assumed that lipopolysaccharide resistance is controlled by the same gene which also effects an impaired response to neutrophil mobilization after prostaglandin application.
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