骨组织中雌激素受体相关受体α (ERRÃÂ±)

Endocrinology and Metabolic Syndrome Pub Date : 2016-07-14 DOI:10.4172/2161-1017.1000244

E. Bonnelye

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引用次数: 2

摘要

雌激素受体相关受体α (Estrogen receptor related receptor α， ERRα)是最古老的孤儿核受体，其序列与雌激素受体ERα/β相同。对ERRα和er的序列比对显示，它们在dna结合结构域具有较高的相似性(68%)，而在配体结合E结构域等蛋白质其他部分具有中等的相似性(36%)。

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Estrogen Receptor Related Receptor Alpha (ERRÃÂ±) in Skeletal Tissues

Estrogen receptor related receptor alpha (ERRα) was the oldest orphan nuclear receptor with sequence identity to the estrogen receptors, ERα/β. The sequence alignment of the ERRα and the ERs reveals a high similarity (68%) in the DNA-binding domain and a moderate similarity (36%) in other parts of the proteins such as the ligand-binding E domain.

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Endocrinology and Metabolic Syndrome

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