肝移植后患者肝功能检测研究的意义

M. Nakashidze, Z. Chikhladze, David Kobuladze, David Beridze
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摘要

近年来,肝移植术后患者的生存率有了明显的提高。然而,成功的移植与术后患者的适当管理直接相关,包括根据实验室检查结果考虑基本方面。因此,研究肝脏功能状态的实验室特征是非常必要的。本研究研究了术后患者肝功能指标:丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)、白蛋白、总胆红素、γ -谷氨酰转移酶(GGT)。采用静脉血进行调查。研究共10例移植后患者。采用了适当的研究方法。P<0.05为差异有统计学意义。总之,我们的研究结果表明,术后患者肝脏面板的强化检查对复杂患者的正确管理有重要作用,直接影响最终结果。值得注意的是,GGT和ALP的变异性可能与肝脏移植的慢性免疫反应直接相关,并可能作为诊断胆道并发症的早期标志。
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THE SIGNIFICANCE OF THE STUDY OF THE LIVER FUNCTION TEST WITHIN POST-TRANSPLANT PATIENTS
In recent years, the survival rate of patients after liver transplantation (LT) has improved significantly. However, successful transplantation is directly related to the proper management of the patient after surgery, including considering essential aspects based on the results of laboratory tests. Therefore, it is essential to study the laboratory characteristics to investigate the functional state of the liver. In the present study, we investigated the indicators of liver function in postoperative patients: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, total bilirubin, gamma-glutamyl transferase (GGT). Venous blood samples were used for investigation. A total of 10 post-transplant patients were studied. Appropriate research methods were used. P<0.05 was considered statistically significant. Overall, our results have shown that intensive examinations of the liver panel in postoperative patients significantly contribute to the proper management of the complicated patient, which directly impacts the final results. Notably, the variability of GGT and ALP may be directly related to the transplanted chronic immune response of the liver and may be used as an early marker for the diagnosis of biliary complications.
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