巴格达市刚地弓形虫感染流产妇女某些免疫标志物水平的测定

Sanaa Ahmed, H. Khalaf, N. Jafar, B. Noomi
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摘要

刚地弓形虫是世界上最常见的人类寄生虫之一,血清学研究表明,世界上超过三分之一的人口感染了这种寄生虫。这种寄生虫是孕妇流产的主要原因之一,主要发生在感染的急性期和妊娠早期。本研究旨在检测孕妇弓形虫及其与某些免疫学指标的关系。从流产妇女(流产后15天内)抽取50份血样(5ml),从健康妇女抽取10份血样作为对照。血清检测IL-8、IL-10、IL-17和IFN-γ。结果表明,弓形虫引起的妊娠早期流产率为68%。大多数流产妇女(76%)年龄在25-30岁之间。在免疫指标方面,弓形虫流产妇女IL-8、IL-10、IL-17和IFN-γ较健康妇女显著升高。弓形虫阳性患者与其他原因流产的妇女相比,这些指标也较高,但这些免疫指标的增加并不显著。本研究认为弓形虫仍是妇女流产的主要原因,其与IL-8、IL-10、IL-17、IFN-γ等免疫标志物显著升高有关。
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Estimation of the Levels of some Immunological Markers in Aborted Women Infected with Toxoplasma gondii at Baghdad City
Toxoplasma gondii is one of the most common parasites among humans worldwide, as serological studies indicate that more than one third of the population of the world is infected with this parasite. This parasite is one of the main causes of abortion in pregnant women which mainly occur in the acute phase of infection and in early pregnancy. The present study aimed to detect toxoplasma among pregnant women and its relationship with some immunological markers. Fifty blood samples (5ml) were collected from aborted woman (within 15 days after abortion) and 10 blood samples collected from healthy woman as control. The serums were used to evaluate IL-8, IL-10, IL-17, and IFN-γ. The results showed that toxoplasma caused abortion in the first trimester in rate of 68%. The majority of aborted women (76%) were at age group 25-30 years. As for immunological parameters, IL-8, IL-10, IL-17, and IFN-γ significantly increased in woman aborted with toxoplasmosis in compare with healthy woman. The parameters were also higher among toxoplasma positive patients when compared with aborted women with other cause but these increases in the immunological parameters were not significant. The study conclude that toxoplasma is still the main causes of abortion in women and it associated with significant increase in immunological markers represented by IL-8, IL-10, IL-17, and IFN-γ.
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