印度中部农村地区乳腺癌激素受体状态与其他预后因素相关性的前瞻性观察研究

R. Gore, Tanweerul Huda, B. Pandya
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摘要

乳腺癌是现代印度的一个主要问题。不断增长的患者人数和不断增加的死亡人数需要科学界和医学界立即予以关注。患者的年龄、社会经济条件和疾病意识在疾病的发生和发展中起着至关重要的作用。在这项研究中,我们在2012年至2014年间进行了严格的调查,并调查了与该疾病相关的所有可能的背景。从社会经济到临床和组织病理学的相关性进行了探讨。对112例患者进行了详细分析。我们的数据显示,印度的情况不仅在发病阶段存在差异,生存率较低,而且发病年龄也比西方研究早近10年。只有8%的参与患者被发现是无产的。极少患者(11.60%)与该病有遗传联系。ER状态、PR状态、淋巴结与患者年龄有统计学相关性。我们的研究既显示了与早期研究的相似之处,也显示了某些事实的不同之处。我们期望这项研究将增加目前对印度乳腺癌的了解。
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A Prospective Observational Study of the Correlation between Hormone Receptor Status and Other Prognostic Factors in Carcinoma Breast in a Rural Set Up in Central India
Breast cancer is a major concern in modern India. The growing population of the patients and the increased death toll require immediate attention from the scientific and medical community. Patientsi¯ age, socio-economic condition, and disease awareness play vital roles in the disease onset and progression. In this study, we have conducted a rigorous survey between 2012 and 2014 and investigated all possible contexts in relevance to the disease. From socio-economic to clinical and histopathological relevance were explored. Detail analysis was done for 112 patients. Our data shows Indian scenario having differences not only in stage at presentation with poorer survival but also that the age at presentation is almost a decade earlier than western studies. Only 8% of the participant patients were found to be nulliparous. Very few patients (11.60%) were found to be linked with the disease hereditarily. Statistical co-relation was found between ER status, PR status, lymph nodes, and age of the patients. Our study has shown similarity with the earlier studies as well as dissimilarity in certain facts. We expect this study will increase the present understanding of breast cancer in India.
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