Covid-19突变株和疫苗现状——系统综述

P. Somasundaram, P. Shanmugasundaram
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摘要

新冠肺炎病毒在中国湖北省被发现,目前已传播到200多个国家。南非变体B 351 P和巴西变种1已经成为一个主要的威胁,因为他们有很高的毒性,这不是受到某些疫苗产生的中和抗体的影响,进一步covid飓风也已成为一个新的威胁突变主要发生在峰值蛋白质尤其是在S1亚单位,(1)突变或氨基酸变化主要发生在该地区从D G的几种疫苗在临床试验显示效果针对这些突变株(mrna 1273, BNT-162b2和covishield)的疫苗的发现,生产和有效性是一个很大的期望,有10种疫苗已经投入使用,还有20多种疫苗等待批准,还有更多的疫苗正在研究中。所有这些疫苗大致分为四种类型灭活疫苗或减毒疫苗,蛋白质疫苗,病毒载体疫苗,RNA和DNA疫苗本文旨在介绍covid - 19突变株、疫苗类型和针对突变株的疫苗的有效性(2)。
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Mutant Strains Of Covid-19 And Current Status Of Vaccines – A Systematic Review
The covid19 virus was found in the hubei province of china and it had now spread to more than 200 countries, The emergence of mutant strains mainly UK variant B 1 1 7, south African variant B 1 351 and the Brazilian variant P 1 have become a major threat,since they have a high virulence and it is not affected by the neutralizing antibodies produced by some vaccines,Furthur covid hurricane had also become a new threat Mutations mainly occur in the Spike protein especially in the S1 subunit,(1) The mutational changes or amino acid changes mainly occur in the region from D to G The are several vaccines which are showing efficacy during their clinical trial against these mutant strains (M rna 1273, BNT-162b2 and the covishield) The is a big expectation regarding the discovery, production and effectiveness of Vaccine With ten vaccines already reaching people there are twenty more vaccines waiting for the approval and there are many more which are under investigations All these vaccines are broadly under four types Inactivated or Attenuated Vaccine, Protein based vaccine, Viral vector vaccine, RNA and DNA vaccines This article is aimed to describe about the mutant strains of covid19, types of vaccine and effectiveness of vaccine against the mutant strains (2)
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