Evaluation of fresh demineralized dentin graft with or without concentrated growth factor in guided bone regeneration around dental implant

Objectives The aim of this study was to evaluate clinically and radiographically, the effectiveness of autologous demineralized dentin graft with or without concentrated growth factor (CGF) around immediate-delayed implant in type II sockets in patients with advanced chronic periodontitis. Materials and methods In the present study, 16 sites with periodontally hopeless single rooted teeth in nine patients. Sites were divided randomly into: group I, which was treated with autologous demineralized dentin graft, and group II was treated with autologous demineralized dentin graft with CGF. At time of crown placement after 6, 9- and 12-months probing pocket depth and bleeding on probing around implant were assessed. Radiographically, facial bone thickness (FBT) and bone density were estimated by using standardized cone beam computed tomography after tooth extraction, immediately after surgery, nine and twelve months later. Results Regarding clinical parameters, both groups showed nonsignificant differences after 6, 9, and 12 months as compared to baseline measures. Upon comparing the groups in terms of pocket depth and bleeding on probing, also showed nonsignificant difference at all study evaluation periods. Radiographic analysis by cone beam computed tomography showed a significant reduction in FBT in two groups at 9 and 12 months as compared to thickness immediately after implant placement. On the other hand, there was a nonstatistically significant difference in FBT between both groups. Regarding bone density, the results showed significant increase in bone density in two groups without significant difference between both groups however, more density was observed in group II. Conclusion The combined treatment of CGF with autologous demineralized dentin graft showed better results, however nonsignificant difference was noted radiographically when compared with autologous demineralized dentin graft alone, it was therefore postulated that, the addition of CGF to autologous demineralized dentin graft may have been a promising outcomed in the field of periodontal regeneration.