产后早期中断母乳喂养诱导的代谢综合征模型雄性大鼠的激素和代谢状况

A. Shpakov, V. Bondareva, K. Derkach
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摘要

在产后早期短期剥夺大鼠幼崽的母乳喂养可导致4-6个月大的多发性硬化症。然而,这种新生儿MS模型需要优化和对成年动物代谢和激素参数的详细研究。这项工作的目的是在19-21日龄被剥夺母乳的成年雄性大鼠中研究这些参数,这是通过给哺乳期雌性大鼠服用溴隐亭来实现的。成年雄性大鼠表现出体重和脂肪组织增加,葡萄糖耐量受损,胰岛素抵抗和高瘦素血症。这些动物的睾酮、游离甲状腺素和总三碘甲状腺原氨酸水平降低,而促甲状腺激素水平升高。因此,短期剥夺成年大鼠的母乳喂养会导致MS的发展和内分泌失调。
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Hormonal and Metabolic Status of Male Rats with Metabolic Syndrome Model Induced by Interruption of Breastfeeding in the Early Postnatal Period
A short-term deprivation of rat pups from breastfeeding in the early postnatal period leads to MS at the age of 4-6 months. However, this neonatal MS model requires optimization and a detailed study into the metabolic and hormonal parameters of adult animals. The aim of the work was to study these parameters in adult male rats deprived of breast milk at the age of 19-21 days, which was achieved by treating lactating females with bromocriptine. Adult male rats showed an increased body weight and adipose tissue, impaired glucose tolerance, insulin resistance, and hyperleptinemia. These animals had reduced levels of testosterone, free thyroxine, and total triiodothyronine, with an increase in the thyroid-stimulating hormone. Thus, a short-term deprivation of breastfeeding in adult rats leads to the development of MS and endocrine dysregulations.
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