Nanoneedle Mediated Delivery of Silver for Topical Therapies

We explored the nanoneedles− a novel nanostructured material (NSM) fabricated by nanofabrication techniques and assessed their suitability as a carrier for delivery of silver drug cargo. We achieved individual nanoneedles with tip diameter of 220-250 nm, desired micro-scale length, high Young’s modulus (~100 GPa), and large external surfaces. Owing to large external surfaces of nanoneedles compared to micro-carriers utilized to deliver cargo of drug substances for topical drug delivery. Drug molecules were conjugated on nanoneedle surface and then released by means of predesigned surface chemistry. SEM, TEM, FTIR, XRD and TGA confirmed surface morphologies, structure of nanoneedles. SQUID magneto-meter was used to ascertain the magnetic behavior of nanoneedles. In vivo methods were carried out to assess wound healing potential of Silver Chitosan nanoneedle, wherein it shows the better results for wound healing. Thus, it could provide better scaffold for wound healing in near future.