生姜乙醇提取物与阿托伐他汀对大鼠血脂影响的比较研究

A. Berroukche, A. Attaoui, M. Loth
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引用次数: 1

摘要

黄姜以其降胆固醇和抗氧化特性而闻名。传统医学的使用减少了有毒性风险的药物的使用。本研究旨在探讨officinale乙醇提取物和阿托伐他汀对高脂饲料喂养大鼠脂质参数的影响。实验在9周内对40只大鼠进行。实验动物分为4组;1组(正常健康对照)、2组(高胆固醇血症饮食对照)、3组(用中药乙醇提取物500 mg/kg/d治疗)和4组(用阿托伐他汀20 mg/kg/d治疗)。结果显示,在第3组和第4组中,体重稳定(289对282克),胆固醇(295.9对275.1毫克/分升)、总甘油三酯(46.8对41.9毫克/分升)和低密度脂蛋白(278.2对259.1毫克/分升)显著降低,但高密度脂蛋白(8.6对7.8毫克/分升)没有显著增加。结果表明,在治疗有肥胖和心血管疾病风险的患者时,Z. officinale与阿托伐他汀具有相似的降胆固醇作用。因此,含姜和低剂量他汀类药物的联合治疗方案可能有利于治疗高胆固醇血症患者。关键词:生姜,胆固醇,抗氧化剂,阿托伐他汀,心血管疾病
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Comparative study between effects of ethanol extract of Zingiber officinale and Atorvastatine on lipid profile in rats
Zingiber officinale is known for its cholesterol-lowering and antioxidant properties. The use of traditional medicine reduces the use of drugs with a risk of toxicity. This study aims to assess the effects of ethanol extract of Z. officinale and atorvastatin on lipid parameters in rats fed with high-fat diet. The experiment was carried out on 40 rats during 9 weeks. The animals were divided into 4 groups; group 1 (normal healthy controls), group 2 (hypercholesterolemic diet controls), group 3 (treated with ethanol extract of Z. officinal at 500 mg / kg / day) and group 4 (treated with Atorvastatin at 20 mg/kg/day). It has been shown, respectively in groups 3  and 4, a stable body weight (289 vs 282 g)  and a highly significant reduction of cholesterol (295.9 vs 275.1 mg/dl), total triglycerides (46.8 vs 41.9 mg/dl) and LDL (278.2 vs 259.1 mg/dl), but not a significant increase in HDL (8.6 vs 7.8 mg/dl). Results showed that Z. officinale is similar to Atorvastatin as a cholesterol-lowering agent in the treatment of patients exposed to risk of obesity and cardiovascular disease. Therefore, combination regimens containing ginger and low dose of statins could be advantageous in treating hypercholesterolemic patients. Key words: Zingiber officinale, cholesterol, antioxidant, Atorvastatine, cardiovascular disease.
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