Delphine Ohayon, Alessia De Chiara, P. M. Dang, N. Thieblemont, Simon M. Chatfield, V. Marzaioli, S. S. Burgener, Julie Mocek, C. Candalh, Coralie Pintard, P. Tacnet-Delorme, G. Renault, I. Lagoutte, M. Favier, Francine Walker, M. Hurtado-Nedelec, D. Desplancq, E. Weiss, C. Benarafa, D. Housset, J. Marie, P. Frachet, J. El-Benna, V. Witko-Sarsat
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Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils
This study describes a novel function of cytosolic proliferating cell nuclear antigen (PCNA) in the control of neutrophil NADPH oxidase, a complex pivotal for ROS generation in inflammation. Inhibition of neutrophil PCNA results in a potent antiinflammatory effect in colitis.
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