支持细胞在损伤相关睾丸生殖细胞凋亡中的作用。

K. Boekelheide, Shawna L. Fleming, Kamin J. Johnson, Sutchin R. Patel, H. Schoenfeld
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引用次数: 114

摘要

本文综述了支持细胞损伤导致生殖细胞凋亡的实验模型。由于生殖细胞存在于由支持细胞创造的环境中,这些密切相关细胞之间的旁分泌信号必须调节生殖细胞死亡的过程。生殖细胞凋亡的信号可能是支持细胞促存活因子的减少,支持细胞促凋亡因子的增加,或两者兼而有之。不同的支持细胞损伤模型表明,精子发生容易受到破坏,针对关键的支持细胞功能可导致快速和大量的生殖细胞死亡。
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Role of Sertoli cells in injury-associated testicular germ cell apoptosis.
This review examines experimental models of Sertoli cell injury resulting in germ cell apoptosis. Since germ cells exist in an environment created by Sertoli cells, paracrine signaling between these intimately associated cells must regulate the process of germ cell death. Germ cell apoptosis may be signaled by a decrease in Sertoli cell pro-survival factors, an increase in Sertoli cell pro-apoptotic factors, or both. The different models of Sertoli cell injury indicate that spermatogenesis is susceptible to disruption, and that targeting critical Sertoli cell functions can lead to rapid and massive germ cell death.
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