抗菌药物4-氨基-5-(氯取代苯基)- 4h -1,2,4-三唑-3-硫酮席夫碱的合成及评价

Kishor Devkota, G. Pathak, B. Shakya
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引用次数: 6

摘要

由于三唑环具有与生物系统相互作用的广泛潜力,它已引起了有机合成化学家和药物化合物研究人员不断增长的兴趣。希夫碱也被认为是最具生物活性的化合物之一。本研究的目的是合成新的含三唑核的希夫碱并评价其抗菌活性。以三唑核和希夫碱基团为载体,合成了4个新的1,2,4-三唑-3-硫酮希夫碱衍生物,并用紫外、红外和核磁共振等光谱技术对其进行了表征。对希夫碱基的抗菌(金黄色葡萄球菌、大肠杆菌和肺炎克雷伯菌)和抗真菌(白色念珠菌)活性进行了评估。合成的化合物对不同菌株的细菌和真菌具有良好到中等的活性。
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Synthesis and Evaluation of Schiff Bases of 4-Amino-5-(chlorine substituted phenyl)-4H-1,2,4-triazole-3-thione as Antimicrobial Agents
Triazole ring system has attracted a continuously growing interest of synthetic organic chemists and those dealing with the medicinal compounds due to its versatile potential to interact with biological systems. Schiff bases are also considered as one of the most biologically active compounds. The aim of the present study was to synthesize new Schiff bases bearing triazole nucleus and to assess their antimicrobial activities. Four new Schiff base derivatives of 1,2,4-triazole-3-thione were synthesized by combining two different pharmacophores viz. triazole nucleus and Schiff base moiety and were characterized by spectral techniques (UV, FT-IR, and NMR). The Schiff bases were evaluated for antibacterial (Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae) and antifungal (Candida albicans) activities. The synthesized compounds exhibited good to moderate activities against different strains of bacteria and fungi tested.
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