在3t交错视觉刺激下的功能性MRS实验中,光谱峰面积没有变化

Q2 Physics and Astronomy Physical Sciences Reviews Pub Date : 2023-03-24 DOI:10.1515/psr-2022-0301
A. N. Mumuni, J. McLean, G. Waiter
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引用次数: 0

摘要

功能磁共振波谱(fMRS)可以定量探测大脑对视觉刺激的反应,这依赖于血氧水平依赖(BOLD)对比机制。fMRS中的BOLD效应与MR光谱的面积、宽度和高度的变化有关。本文研究了光谱平均方案(NEX值)对光谱中BOLD变化的影响。采用单次和交错刺激模式下的8 Hz视觉刺激,比较3名健康志愿者(平均年龄±SD = 32.7±3.5岁)枕脑区获得的两组fMRS数据集的BOLD效应,这些数据集在3 T MR扫描仪上可获得两个NEX值(“2”和“8”)。使用SAGE软件包(版本7)估计BOLD信号的变化为六种脑代谢物和水的光谱面积、高度和宽度的百分比变化。在两种刺激模式中,NEX = 8时BOLD效应的总体趋势较低。在单次刺激模式下,NEX = 8与n -乙酰天冬氨酸(NAA)光谱高度(p = 0.03)、肌酸(p = 0.04)和胆碱(p = 0.02)光谱宽度以及NAA (p = 0.03)、水(p < 0.01)和谷氨酸(p = 0.02)光谱面积显著降低相关。在交错刺激模式下,NEX = 8与谷氨酸光谱高度(p = 0.02)、水(p = 0.03)和谷氨酰胺(p = 0.03)光谱宽度显著降低相关,但两种NEX值在所有光谱区域均无显著差异。尽管两种NEX值在可观察到的BOLD效果上存在一定差异,但在交错视觉刺激实验中,它们的光谱面积没有显著差异。
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Spectral peak areas do not vary according to spectral averaging scheme used in functional MRS experiments at 3 T with interleaved visual stimulation
Abstract Brain response to visual stimulation can be probed quantitatively using functional magnetic resonance spectroscopy (fMRS), which relies on the blood oxygenation level dependent (BOLD) contrast mechanism. BOLD effect in fMRS is associated with changes in the areas, widths, and heights of the MR spectra. This study investigated the effect of spectral averaging scheme (NEX value) on BOLD changes in the spectra. Using a visual stimulus at 8 Hz in single and interleaved stimulation paradigms, the BOLD effects in spectra acquired from the occipital brain region of three healthy volunteers (mean age ± SD = 32.7 ± 3.5 years) were compared for two fMRS data sets acquired with two NEX values (“2” and “8”) available on a 3 T MR scanner. BOLD signal changes were estimated as percentage changes in spectral areas, heights, and widths of six cerebral metabolites and water using the SAGE software package (version 7). There was a general trend of lower BOLD effects with NEX = 8 in both stimulation paradigms. In the single stimulation paradigm, NEX = 8 was associated with significantly lower N-acetyl aspartate (NAA) spectral height (p = 0.03), creatine (p = 0.04) and choline (p = 0.02) spectral widths, and NAA (p = 0.03), water (p < 0.01), and glutamate (p = 0.02) spectral areas. In the interleaved stimulation paradigm, NEX = 8 was associated with significantly lower glutamate spectral height (p = 0.02), water (p = 0.03), and glutamine (p = 0.03) spectral widths, but there was no significant difference in all spectral areas between the two NEX values. Even though the two NEX values offered some differences in observable BOLD effects, their spectral areas were not significantly different in the interleaved visual stimulation experiments.
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来源期刊
Physical Sciences Reviews
Physical Sciences Reviews MULTIDISCIPLINARY SCIENCES-
CiteScore
2.40
自引率
0.00%
发文量
173
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