毒蛇毒对哺乳动物体内平衡作用的环境和生物学意义

O. Mudrak, O. Maievskyi, A. Parfenyuk, Yevheniia Tkach, O. Tertychna
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摘要

这篇文章考察了动物毒素作为一种进化适应的作用的生态和生物学意义,这种进化适应使25万多种物种对其栖息地的条件进行了最大程度的适应。研究发现,动物毒物对生态系统中各种连接形式的形成和过程具有重要影响,具有多种生态功能,是重要的环境生物因子。研究得最好的有毒动物是蛇,有3800多种不同的种类,只有一小部分是剧毒的。毒蛇科包括101种毒蛇。在欧洲,ammodytes蝰蛇、aspis蝰蛇、Vipera berus、Vipera latastei、Vipera seoanei和Vipera ursinii是最危险的种类,它们的叮咬会导致严重中毒。在乌克兰,毒蛇属的代表是草原毒蛇(Vipera renardi (Cristoph, 1861))和普通毒蛇(Vipera berus (Linnaeus, 1758))的两个亚种- Vipera berus berus和Nikolsky毒蛇(Vipera berus nikolskii, Vedmederja Grubant et Rudaeva, 1986)。给出了影响蛇毒成分多样性的因素。蛇毒是蛋白质、多肽和低分子量物质的复杂混合物,其中酶和非酶成分有明显区别。蛇毒的生物学特性在很大程度上取决于其成分的特性,这些成分对生物体的总体稳态状态有广泛的影响。本文对雷纳尔迪蝰蛇、尼古斯基蝰蛇和贝鲁斯蝰蛇毒液的化学成分及其对哺乳动物身体功能的影响进行了综合研究。结果发现,对哺乳动物(小鼠)毒性最大的是尼古斯基蝰蛇(Vipera berus nikolski),毒性最小的是雷氏蝰蛇(Vipera renardi)。研究了尼古斯基蝮蛇和尼古斯基蝮蛇毒液对大鼠各器官蛋白水解平衡的影响。强调蛇毒毒素在许多科学领域具有尚未充分开发的巨大潜力,因此值得进一步的实际研究。
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Environmental and biological significance of the action of viper poison on the homeostasis of mammals
The article examines the ecological and biological significance of the action of animal poisons as an evolutionary adaptation that maximizes the adaptation of more than 250,000 species to the conditions of their habitat. It was found that animal poisons have a significant impact on the formation and course of various forms of connections in ecosystems, perform several ecological functions and are important biotic factors of the environment. The best-studied venomous animals have been found to be snakes, of over 3,800 different species, only a small number are highly venomous. The Viperidae family includes 101 species of poisonous snakes. In Europe, Vipera ammodytes, Vipera aspis, Vipera berus, Vipera latastei, Vipera seoanei and Vipera ursinii are the most dangerous species, their bites cause severe poisoning. In Ukraine, the genus Vipera is represented by the steppe viper (Vipera renardi (Cristoph, 1861)) and two subspecies of the common viper (Vipera berus (Linnaeus, 1758)) — Vipera berus berus and Nikolsky’s viper (Vipera berus nikolskii, Vedmederja Grubant et Rudaeva, 1986). The factors that affect the diversity of the composition of snake venom are given. It is noted that snake venoms are complex mixtures of proteins, peptides and low molecular weight substances, among which enzymes and non-enzymatic components are distinguished. The biological properties of snake venom depend significantly on the properties of its components, which have a wide range of effects on the general state of homeostasis of a living organism. A generalization of scientific data on the study of the chemical composition of the venom of Vipera renardi, Vipera berus nikolskii and Vipera berus berus and the effects of these venoms on the functioning of the mammalian body has been carried out. It was found that the venom of Vipera berus nikolskii is the most, and Vipera renardi — the least toxic for mammals (mice). The effect of Vipera berus nikolskii and Vipera berus berus venom on the proteolytic balance of individual organs of rats was evaluated. It is emphasized that viper venom toxins have a great, not yet fully developed potential in many scientific fields, therefore they deserve further practical research.
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