CALB最近的去对称反应

S. Niwayama
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引用次数: 2

摘要

酶反应是有机合成中最环保、最重要的不对称反应之一。南极念珠菌脂肪酶B (CALB)是各种不对称反应中应用最广泛的酶之一。它催化多种不对称反应,如水解、酯化和酰胺化。然而,由于CALB催化对称化合物的去对称反应的研究相当有限,本文主要介绍最近CALB介导的去对称反应的一些例子。
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Recent Desymmetrization Reactions By CALB
Enzyme reactions are among the most environmentally friendly and important asymmetric reactions for organic synthesis. Candida Antarctica lipase B (CALB) is one of the most extensively utilized enzymes for various asymmetric reactions. It catalyzes a variety of asymmetric reactions, such as hydrolysis, esterification, and amidation. However, as the studies of desymmetrization reactions of symmetric compounds catalyzed by CALB is rather limited, this commentary focuses on some recent examples of desymmetrization reactions mediated by CALB.
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