多发性硬化症患者慢性脑脊髓静脉功能不全:来自伊朗的病例对照研究

Perspectives in Medicine Pub Date : 2012-09-01 DOI:10.1016/j.permed.2012.02.037

Masoud Mehrpour , Neda Najimi , Seyed-Mohammad Fereshtehnejad , Fatemeh Naderi Safa , Samira Mirzaeizadeh , Mohammad Reza Motamed , Masoud Nabavi , Mohammad Ali Sahraeian

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引用次数: 6

摘要

慢性脑脊髓静脉功能不全(CCSVI)是一种新发现的多发性硬化症(MS)的病因。我们的目的是评估CCSVI与MS与对照组的关系。方法选取84例多发性硬化症患者和115例健康对照者。至少两项颅外和/或颅内Zamboni标准的存在被认为是CCSVI的阳性证据。结果尽管符合CCSVI标准的MS患者总数明显高于对照组(22.6%比10.4%，P = 0.019)，但84例患者中只有1例符合Zamboni标准(1.2%比0,P = 0.422)。结论我们的研究结果不支持MS与Zamboni定义的CCSVI标准之间存在关系。

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Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis: A case-control study from Iran

Introduction

Chronic cerebrospinal venous insufficiency (CCSVI) is a newly suggested cause for multiple sclerosis (MS) detected by color-coded Doppler sonography. Our aim was to evaluate the relationship between CCSVI and MS compared to the control group.

Methods

The study was performed on 84 MS patients and 115 healthy subjects. The presence of at least two of the extra- and/or intra-cranial Zamboni's criteria was considered positive for evidence of CCSVI.

Results

Although the total number of MS patients with any detectable CCSVI criterion was significantly higher than the controls (22.6% vs. 10.4%, P = 0.019), only one out of 84 patients fulfilled the Zamboni's criteria (1.2% vs. none, P = 0.422).