{"title":"芦笋根甲醇提取物对实验动物非血管平滑肌的影响","authors":"P. Nwafor, F. Okwuasaba, M. O. Uguru","doi":"10.4314/WAJPDR.V21I1.14756","DOIUrl":null,"url":null,"abstract":"The effect of methanolic extract of Asparagus pubescens root was investigated on non-vascular smooth muscle in experimental animals. The extract dose-dependently reduced spontaneous rhythmic contraction of rat uterine smooth muscle. It also inhibited acetylcholine, ergometrine, oxytocin, prostaglandin E2, 5-hydroxytryptamine as well as nicotine-induced contractions on rat uterine muscle. \nThese dose-related inhibitions were statistically significant (p Keywords : Asparagus pubescens , non-vascular smooth muscle, methanolic extract, non-specific mechanism West African Journal of Pharmacology and Drug Research Vol. 21 (1&2) 2005: pp. 31-36","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"13 1","pages":"31-36"},"PeriodicalIF":0.0000,"publicationDate":"2007-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Effect of methanolic extract of Asparagus pubescens root on non-vascular smooth muscle in experimental animals\",\"authors\":\"P. Nwafor, F. Okwuasaba, M. O. Uguru\",\"doi\":\"10.4314/WAJPDR.V21I1.14756\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The effect of methanolic extract of Asparagus pubescens root was investigated on non-vascular smooth muscle in experimental animals. The extract dose-dependently reduced spontaneous rhythmic contraction of rat uterine smooth muscle. It also inhibited acetylcholine, ergometrine, oxytocin, prostaglandin E2, 5-hydroxytryptamine as well as nicotine-induced contractions on rat uterine muscle. \\nThese dose-related inhibitions were statistically significant (p Keywords : Asparagus pubescens , non-vascular smooth muscle, methanolic extract, non-specific mechanism West African Journal of Pharmacology and Drug Research Vol. 21 (1&2) 2005: pp. 31-36\",\"PeriodicalId\":23624,\"journal\":{\"name\":\"West African journal of pharmacology and drug research\",\"volume\":\"13 1\",\"pages\":\"31-36\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2007-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"West African journal of pharmacology and drug research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/WAJPDR.V21I1.14756\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"West African journal of pharmacology and drug research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/WAJPDR.V21I1.14756","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
摘要
研究了芦笋根甲醇提取物对实验动物非血管平滑肌的影响。提取物剂量依赖性地减少大鼠子宫平滑肌自发节律性收缩。它还能抑制乙酰胆碱、麦角新碱、催产素、前列腺素E2、5-羟色胺以及尼古丁引起的大鼠子宫肌肉收缩。关键词:短毛芦笋，非血管平滑肌，甲醇提取物，非特异性机制《西非药理学与药物研究》Vol. 21 (1&2) 2005: pp. 31-36
Effect of methanolic extract of Asparagus pubescens root on non-vascular smooth muscle in experimental animals
The effect of methanolic extract of Asparagus pubescens root was investigated on non-vascular smooth muscle in experimental animals. The extract dose-dependently reduced spontaneous rhythmic contraction of rat uterine smooth muscle. It also inhibited acetylcholine, ergometrine, oxytocin, prostaglandin E2, 5-hydroxytryptamine as well as nicotine-induced contractions on rat uterine muscle.
These dose-related inhibitions were statistically significant (p Keywords : Asparagus pubescens , non-vascular smooth muscle, methanolic extract, non-specific mechanism West African Journal of Pharmacology and Drug Research Vol. 21 (1&2) 2005: pp. 31-36
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