{"title":"硼酸曼尼希反应","authors":"S. Pyne, M. Tang","doi":"10.1002/0471264180.OR083.02","DOIUrl":null,"url":null,"abstract":"The boronic acid Mannich reaction is a three-component reaction between a carbonyl compound (aldehyde or ketone), an amine (primary or secondary) and a boronic acid. This chapter addresses the mechanism, stereochemistry, and the scope and limitations of each of the three components of this reaction. Some typical experimental conditions are provided along with a comprehensive Tabular Survey. \n \n \n \nThis three-component reaction is extremely versatile for preparing important chiral starting materials for the synthesis of molecules of biological interest, including chiral α-amino acids, 1,2-amino alcohols, 2-aminoalkyl phenols, heterocycles, and alkaloids as shown in the general scheme below. \n \n \nKeywords: \n \nmulticomponent reactions; \nPetasis reaction","PeriodicalId":19539,"journal":{"name":"Organic Reactions","volume":"17 1","pages":"211-498"},"PeriodicalIF":0.0000,"publicationDate":"2013-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"The Boronic Acid Mannich Reaction\",\"authors\":\"S. Pyne, M. Tang\",\"doi\":\"10.1002/0471264180.OR083.02\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The boronic acid Mannich reaction is a three-component reaction between a carbonyl compound (aldehyde or ketone), an amine (primary or secondary) and a boronic acid. This chapter addresses the mechanism, stereochemistry, and the scope and limitations of each of the three components of this reaction. Some typical experimental conditions are provided along with a comprehensive Tabular Survey. \\n \\n \\n \\nThis three-component reaction is extremely versatile for preparing important chiral starting materials for the synthesis of molecules of biological interest, including chiral α-amino acids, 1,2-amino alcohols, 2-aminoalkyl phenols, heterocycles, and alkaloids as shown in the general scheme below. \\n \\n \\nKeywords: \\n \\nmulticomponent reactions; \\nPetasis reaction\",\"PeriodicalId\":19539,\"journal\":{\"name\":\"Organic Reactions\",\"volume\":\"17 1\",\"pages\":\"211-498\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-04-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic Reactions\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/0471264180.OR083.02\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Reactions","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/0471264180.OR083.02","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The boronic acid Mannich reaction is a three-component reaction between a carbonyl compound (aldehyde or ketone), an amine (primary or secondary) and a boronic acid. This chapter addresses the mechanism, stereochemistry, and the scope and limitations of each of the three components of this reaction. Some typical experimental conditions are provided along with a comprehensive Tabular Survey.
This three-component reaction is extremely versatile for preparing important chiral starting materials for the synthesis of molecules of biological interest, including chiral α-amino acids, 1,2-amino alcohols, 2-aminoalkyl phenols, heterocycles, and alkaloids as shown in the general scheme below.
Keywords:
multicomponent reactions;
Petasis reaction
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