1-取代-3-芳基- 1h -吡唑-4-乙醛衍生物的微波辅助合成及QSAR研究

Valmik S. Kapase
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引用次数: 0

摘要

以取代苯乙酮(1a-d)、取代肼(2a-b)和DMF为原料,在POCl3中合成了几种1-取代-3-芳基- 1h -吡唑-4-醛(3a-g)衍生物,并用20%功率微波照射反应混合物,得到1-取代-3-芳基- 1h -吡唑-4-醛衍生物(3a-g)。
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Microwave Assisted Synthesis and QSAR Study of 1-Substituted-3-aryl-1H-pyrazole-4-carbaldehydes Derivatives
Several 1-substituted-3-aryl-1H-pyrazole-4-carbaldehyde (3a-g) derivatives were synthesized by substituted acetophenone (1a-d), substituted hydrazine (2a-b) and DMF in POCl3 and reaction mixture was irradiated with microwave at 20% power to furnish 1-substituted-3-aryl-1H-pyrazole-4-carbaldehydes derivatives (3a-g).
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