Effect of Hyperglycemia on Immune Function

Diabetes Mellitus (DM) is a metabolic disorder which leads to many serious secondary complications like retinopathy, neuropathy, nephropathy, cardiovascular complication, delayed wound healing etc. Diabetics are more prone to infection due to compromised immunity. Hyperglycaemia leads to oxidative and osmotic stress. This short communication is the preliminary study to know the effect of high glucose concentration (mimicking hyperglycemia) and H2O2 (mimicking oxidative stress) on murine macrophage cell line RAW 264.7. Methodology