3 -乳酸菌对环磷酰胺化疗大鼠微生物组和免疫损伤的恢复作用

IF 2.1 Q3 MICROBIOLOGY Microbiology Research Pub Date : 2023-07-06 DOI:10.3390/microbiolres14030059

Shousong Yue, Zhenzhong Zhang, F. Bian, Yan Zhang, Gao Chen, Youfeng Zhu, Jun Li, J. Picimbon

{"title":"3 -乳酸菌对环磷酰胺化疗大鼠微生物组和免疫损伤的恢复作用","authors":"Shousong Yue, Zhenzhong Zhang, F. Bian, Yan Zhang, Gao Chen, Youfeng Zhu, Jun Li, J. Picimbon","doi":"10.3390/microbiolres14030059","DOIUrl":null,"url":null,"abstract":"We deal with various strains of Lactobacillus that can maintain the intestinal microbiome of rats treated with cyclophosphamide, an anticancer agent (chemotherapy). We use MiSeq and various types of statistical tests to prove that cyclophosphamide in rats alters the intestinal microbiome, favoring the growth of various fungi that are extremely harmful to intestinal metabolism. On the contrary, when Lactobacillus 3L is administered together with cyclophosphamide, we prove that the microbiome is preserved by having a much better intestinal metabolism.","PeriodicalId":43788,"journal":{"name":"Microbiology Research","volume":"46 1","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"3L, Three-Lactobacilli on Recovering of Microbiome and Immune-Damage by Cyclophosphamide Chemotherapy—A Pilot Experiment in Rats—\",\"authors\":\"Shousong Yue, Zhenzhong Zhang, F. Bian, Yan Zhang, Gao Chen, Youfeng Zhu, Jun Li, J. Picimbon\",\"doi\":\"10.3390/microbiolres14030059\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We deal with various strains of Lactobacillus that can maintain the intestinal microbiome of rats treated with cyclophosphamide, an anticancer agent (chemotherapy). We use MiSeq and various types of statistical tests to prove that cyclophosphamide in rats alters the intestinal microbiome, favoring the growth of various fungi that are extremely harmful to intestinal metabolism. On the contrary, when Lactobacillus 3L is administered together with cyclophosphamide, we prove that the microbiome is preserved by having a much better intestinal metabolism.\",\"PeriodicalId\":43788,\"journal\":{\"name\":\"Microbiology Research\",\"volume\":\"46 1\",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2023-07-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microbiology Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/microbiolres14030059\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbiology Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/microbiolres14030059","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

我们处理各种乳酸菌菌株，可以维持大鼠的肠道微生物组治疗环磷酰胺，一种抗癌剂(化疗)。我们使用MiSeq和各种类型的统计检验证明，环磷酰胺在大鼠体内改变了肠道微生物组，有利于各种真菌的生长，而这些真菌对肠道代谢极为有害。相反，当乳酸菌3L与环磷酰胺一起施用时，我们证明微生物组通过具有更好的肠道代谢而得到保存。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

3L, Three-Lactobacilli on Recovering of Microbiome and Immune-Damage by Cyclophosphamide Chemotherapy—A Pilot Experiment in Rats—

We deal with various strains of Lactobacillus that can maintain the intestinal microbiome of rats treated with cyclophosphamide, an anticancer agent (chemotherapy). We use MiSeq and various types of statistical tests to prove that cyclophosphamide in rats alters the intestinal microbiome, favoring the growth of various fungi that are extremely harmful to intestinal metabolism. On the contrary, when Lactobacillus 3L is administered together with cyclophosphamide, we prove that the microbiome is preserved by having a much better intestinal metabolism.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Microbiology Research MICROBIOLOGY-

CiteScore

1.90

自引率

6.70%

发文量

审稿时长

10 weeks

期刊介绍： Microbiology Research is an international, online-only, open access peer-reviewed journal which publishes original research, review articles, editorials, perspectives, case reports and brief reports to benefit researchers, microbiologists, physicians, veterinarians. Microbiology Research publishes ‘Clinic’ and ‘Research’ papers divided into two different skill and proficiency levels: ‘Junior’ and ‘Professional’. The aim of this four quadrant grid is to encourage younger researchers, physicians and veterinarians to submit their results even if their studies encompass just a limited set of observations or rely on basic statistical approach, yet upholding the customary sound approach of every scientific article.