非动脉炎性前缺血性视神经病变:未来的挑战。

IF 0.8 4区 社会学 Q3 SOCIOLOGY Contributions To Indian Sociology Pub Date : 2022-03-15 eCollection Date: 2022-01-01 DOI:10.3389/fopht.2022.848710
Alison Gibbons, Amanda D Henderson
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引用次数: 0

摘要

非动脉性前缺血性视神经病变(NAION)是50岁以上人群中最常见的与视力丧失有关的急性单侧视神经病变(ON)(1,2)。然而,尽管这种情况发生的频率高,但没有治疗证明可以改善受NAION影响的患者的视力。患者评估最初侧重于排除模拟者,特别是继发于巨细胞动脉炎的动脉前缺血性视神经病变,以及非典型病例的视神经炎。在确认NAION诊断后,重点转移到确定可改变的危险因素,包括高血压、糖尿病、高脂血症(3)、阻塞性睡眠呼吸暂停(4,5)和磷酸二酯酶-5抑制剂的使用(6,7)。优化可改变的危险因素的治疗可能会降低在同眼发生继发性NAION的风险。NAION的病理生理学虽然尚未完全阐明,但被认为是继发于短后睫状动脉引起的前侧视神经灌注减少,导致视盘肿胀,最终形成隔室综合征(8)。灌注减少的原因(如低血压、微血栓形成、这些因素的组合,或其他完全的原因)尚未得到证实。研究还表明,对初始损伤的炎症反应可能在由此产生的神经元损伤和视力丧失中发挥作用(9,10)。因此,各种潜在的神经保护和神经再生治疗已经(并将继续)被评估。
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来源期刊
CiteScore
1.50
自引率
16.70%
发文量
14
期刊介绍: Contributions to Indian Sociology (CIS) is a peer-reviewed journal which has encouraged and fostered cutting-edge scholarship on South Asian societies and cultures over the last 50 years. Its features include research articles, short comments and book reviews. The journal also publishes special issues to highlight new and significant themes in the discipline. CIS invites articles on all countries of South Asia, the South Asian diaspora as well as on comparative studies related to the region. The journal favours articles in which theory and data are mutually related. It welcomes a diversity of theoretical approaches and methods. CIS was founded by Louis Dumont and David Pocock in 1957 but ceased publication in 1966. A new series commenced publication the next year (1967) at the initiative of T.N. Madan with the support of an international group of scholars including Professors Louis Dumont, A.C. Mayer, Milton Singer and M.N. Srinivas. Published annually till 1974, Contributions became a biannual publication in 1975. From 1999, the journal has been published thrice a year.
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