Egija Zelča, D. Gudrā, Ērika Lūse, Jana Peterleviča, M. Ustinova, D. Fridmanis, I. Rumba-Rozenfelde, I. Daugule
{"title":"主导的早期生命肠道微生物群的分类学组成和影响因素在拉脱维亚婴儿7个月的年龄","authors":"Egija Zelča, D. Gudrā, Ērika Lūse, Jana Peterleviča, M. Ustinova, D. Fridmanis, I. Rumba-Rozenfelde, I. Daugule","doi":"10.2478/prolas-2022-0101","DOIUrl":null,"url":null,"abstract":"Abstract It has been hypothesised that the establishment of stable adult microbiota is programmed in infancy, and therefore early life gut colonisation may lead to a lifelong microbiota pattern with significant effects on health. The aim of the study was to analyse the composition of gut microbiota and influencing factors in infants up to seven months of age in Latvia. A cross-sectional study was performed at primary healthcare centres. The parents of healthy infants filled out a questionnaire and brought the child’s faecal sample. 16 rRNS gene sequencing was performed to identify the bacterial taxonomic units. The composition of gut microbiota was compared between children with different risk factors. The final participant sample group included 55 infants with median age 4.0 months. The infant gut microbiota of the sample group had typical and rather healthy microbiota — the main phyla detected were Firmicutes and Actinobacteria, the main family was Bifidobacteriacea and genus — Bifidobacterium. A significant effect of the type of delivery and feeding type was identified, as well as negative correlation between Lactobacilli and gestational age. Further, it would be important to analyse the changes of microbiota prospectively to identify the association with environmental factors and health status in dynamics.","PeriodicalId":20651,"journal":{"name":"Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.","volume":"68 6 1","pages":"657 - 664"},"PeriodicalIF":0.0000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dominating taxonomic composition of the early life gut microbiota and influencing factors in infants up to seven months of age in Latvia\",\"authors\":\"Egija Zelča, D. Gudrā, Ērika Lūse, Jana Peterleviča, M. Ustinova, D. Fridmanis, I. Rumba-Rozenfelde, I. Daugule\",\"doi\":\"10.2478/prolas-2022-0101\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract It has been hypothesised that the establishment of stable adult microbiota is programmed in infancy, and therefore early life gut colonisation may lead to a lifelong microbiota pattern with significant effects on health. The aim of the study was to analyse the composition of gut microbiota and influencing factors in infants up to seven months of age in Latvia. A cross-sectional study was performed at primary healthcare centres. The parents of healthy infants filled out a questionnaire and brought the child’s faecal sample. 16 rRNS gene sequencing was performed to identify the bacterial taxonomic units. The composition of gut microbiota was compared between children with different risk factors. The final participant sample group included 55 infants with median age 4.0 months. The infant gut microbiota of the sample group had typical and rather healthy microbiota — the main phyla detected were Firmicutes and Actinobacteria, the main family was Bifidobacteriacea and genus — Bifidobacterium. A significant effect of the type of delivery and feeding type was identified, as well as negative correlation between Lactobacilli and gestational age. Further, it would be important to analyse the changes of microbiota prospectively to identify the association with environmental factors and health status in dynamics.\",\"PeriodicalId\":20651,\"journal\":{\"name\":\"Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.\",\"volume\":\"68 6 1\",\"pages\":\"657 - 664\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2478/prolas-2022-0101\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Multidisciplinary\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2478/prolas-2022-0101","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Multidisciplinary","Score":null,"Total":0}
Dominating taxonomic composition of the early life gut microbiota and influencing factors in infants up to seven months of age in Latvia
Abstract It has been hypothesised that the establishment of stable adult microbiota is programmed in infancy, and therefore early life gut colonisation may lead to a lifelong microbiota pattern with significant effects on health. The aim of the study was to analyse the composition of gut microbiota and influencing factors in infants up to seven months of age in Latvia. A cross-sectional study was performed at primary healthcare centres. The parents of healthy infants filled out a questionnaire and brought the child’s faecal sample. 16 rRNS gene sequencing was performed to identify the bacterial taxonomic units. The composition of gut microbiota was compared between children with different risk factors. The final participant sample group included 55 infants with median age 4.0 months. The infant gut microbiota of the sample group had typical and rather healthy microbiota — the main phyla detected were Firmicutes and Actinobacteria, the main family was Bifidobacteriacea and genus — Bifidobacterium. A significant effect of the type of delivery and feeding type was identified, as well as negative correlation between Lactobacilli and gestational age. Further, it would be important to analyse the changes of microbiota prospectively to identify the association with environmental factors and health status in dynamics.