{"title":"醌类衍生物对大鼠乙醇和乙醛代谢的影响","authors":"N. Hobara, A. Watanabe, Y. Gomita, Y. Araki","doi":"10.5649/jjphcs1975.15.33","DOIUrl":null,"url":null,"abstract":"Quinone derivatives, such as 2, 3-dimethoxy-5-methy1-6-decapreny1-1, 4-benzoquinone (ubidecarenone, coenzyme Q10, CoQ10), 4, 5-dihydro-4, 5-dioxo-1H-pyrrolo [2, 3-f] quinoline-2, 7, 9-tricarboxylic acid (pyrroloquinoline quinone, PQQ) and 6-(10-hydroxydecy1)-2, 3-dimethoxy-5-methy1-1, 4-benzoquinone (idebenone), significantly inhibited rise of acetaldehyde concentration in blood and liver of rats following ethanol ingestion.Acetaldehyde concentrations decreased in vitro with incubation with 1, 4-benzoquinone or PQQ solution at 40°C. Low acetaldehyde concentrations following ethanol ingestion might be due to PQQ-accelerated oxidation of acetaldehyde.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"7 1","pages":"33-35"},"PeriodicalIF":0.0000,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of Quinone Derivatives on Ethanol and Acetaldehyde Metabolism in Rats\",\"authors\":\"N. Hobara, A. Watanabe, Y. Gomita, Y. Araki\",\"doi\":\"10.5649/jjphcs1975.15.33\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Quinone derivatives, such as 2, 3-dimethoxy-5-methy1-6-decapreny1-1, 4-benzoquinone (ubidecarenone, coenzyme Q10, CoQ10), 4, 5-dihydro-4, 5-dioxo-1H-pyrrolo [2, 3-f] quinoline-2, 7, 9-tricarboxylic acid (pyrroloquinoline quinone, PQQ) and 6-(10-hydroxydecy1)-2, 3-dimethoxy-5-methy1-1, 4-benzoquinone (idebenone), significantly inhibited rise of acetaldehyde concentration in blood and liver of rats following ethanol ingestion.Acetaldehyde concentrations decreased in vitro with incubation with 1, 4-benzoquinone or PQQ solution at 40°C. Low acetaldehyde concentrations following ethanol ingestion might be due to PQQ-accelerated oxidation of acetaldehyde.\",\"PeriodicalId\":17399,\"journal\":{\"name\":\"Journal of the Nippon Hospital Pharmacists Association\",\"volume\":\"7 1\",\"pages\":\"33-35\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1989-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Nippon Hospital Pharmacists Association\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5649/jjphcs1975.15.33\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Nippon Hospital Pharmacists Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5649/jjphcs1975.15.33","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of Quinone Derivatives on Ethanol and Acetaldehyde Metabolism in Rats
Quinone derivatives, such as 2, 3-dimethoxy-5-methy1-6-decapreny1-1, 4-benzoquinone (ubidecarenone, coenzyme Q10, CoQ10), 4, 5-dihydro-4, 5-dioxo-1H-pyrrolo [2, 3-f] quinoline-2, 7, 9-tricarboxylic acid (pyrroloquinoline quinone, PQQ) and 6-(10-hydroxydecy1)-2, 3-dimethoxy-5-methy1-1, 4-benzoquinone (idebenone), significantly inhibited rise of acetaldehyde concentration in blood and liver of rats following ethanol ingestion.Acetaldehyde concentrations decreased in vitro with incubation with 1, 4-benzoquinone or PQQ solution at 40°C. Low acetaldehyde concentrations following ethanol ingestion might be due to PQQ-accelerated oxidation of acetaldehyde.
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