ABOUT EXPANDING OPTIONS FOR USING BALB/C NUDE MICE FOR EXPERIMENTAL STUDY OF HUMAN MALIGNANT TUMORS IN VIVO

The article has a problematic scripting nature. At the present stage, in addition to objective factors that make it difficult to create adequate experimental models of human oncogenesis, there is a significant backlog of domestic science in the development of this direction. This reduces the availability for Russian specialists of humanized immunodeficient animals corresponding to the level of research tasks. Based on the analysis of literature data, we discuss approaches that can expand the use of a widely available immunodeficiency animal model‑BALB/c nude mice. The possibility of using human mesenchymal stem cells that are not rejected by BALB/C Nude mice for local humanization of immunodeficient animals and improving the structural and functional characteristics of xenografts is considered. The possibility of obtaining xenografts of human glioblasts supported in the body of immunocompetent BALB/c mice after serial passages of organotypic tumor spheroids in the brain of BALB/c nude mice is analyzed.