骨质疏松治疗开始后,最小创伤骨折

Mary G. Etty-Leal, V. Tran, Lara Kusmanoff, D. Pearce, A. Politis, Loren A. Reynolds, D. Sepe, V. Chan
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摘要

目的:确定澳大利亚一家大型三级教学医院收治的50岁及以上确诊股骨颈或椎体轻度创伤性骨折的患者出院时开始接受特定抗骨质疏松治疗的比例,并描述所开药物。方法:回顾性分析6个月内髋部或椎体轻度创伤性骨折患者的电子病历。结果:共审核407例患者,64例患者纳入研究;37人因髋部骨折入院,27人因椎体骨折入院。在这64例患者中,共有14例(21.9%)患者开始接受特异性抗骨质疏松治疗。Denosumab(71%)是最常见的初始治疗,其次是利塞膦酸钠(21%),然后是阿仑膦酸钠(7%)。结论:大多数轻度创伤性骨折患者未在医院开始抗骨质疏松治疗。这是一个错失的干预机会,可能会使患者面临更高的骨折风险;因此,未来应该实施有效的策略来解决这一治疗差距。
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Osteoporosis therapy initiation post-minimal trauma fracture
Aim: To determine the proportion of patients admitted to a major tertiary teaching hospital in Australia aged 50 years and older with a confirmed neck of femur or vertebral minimal trauma fracture, who are commenced on specific antiosteoporosis therapy by discharge, and to describe the agents prescribed. Methods: A retrospective analysis was conducted using patients’ electronic medical files of patients admitted with a minimal trauma fracture of the hip or vertebra during a 6 month period. Results: A total of 407 patients were audited and 64 patients were included in the study; 37 were admitted for a fractured hip and 27 were admitted for a vertebral fracture. Of these 64 patients, a total of 14 (21.9%) patients were commenced on specific anti-osteoporosis therapy. Denosumab (71%) was the most commonly initiated treatment, followed by risedronate (21%) then alendronate (7%). Conclusion: Majority of patients presenting to hospital with a minimal trauma fracture were not commenced on anti-osteoporosis therapy in hospital. This is a missed opportunity for intervention that may place patients at a higher risk of subsequent fracture; therefore effective strategies should be implemented to address this treatment gap in the future.
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