壳聚糖纳米系统作为药物载体

R. Milusheva, S. Rashidova
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引用次数: 0

摘要

高分子纳米材料的形成和应用在科学、工业、生物技术和医学领域有着巨大的需求,因为聚合物的物理化学、机械和屏障性能有可能得到显著改善,并将其用作药物载体和填料,特别是壳聚糖及其衍生物等可生物降解聚合物。本文介绍了基于多糖,特别是壳聚糖的聚合物纳米结构的制备方法。利用多糖的化学转化和改性方法获得壳聚糖的纳米结构样品是一个迫切的科学问题,这一问题的解决使获得具有重大实际意义的新型聚合物体系成为可能。讨论了壳聚糖聚合物载体在各种疾病治疗中的医学应用。壳聚糖及其衍生的纳米材料的独特特性,以及这种天然聚合物固有的特性,可以作为一个有希望的未来,特别是在医学领域。
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Chitosan-based Nanosystems as Drug Carriers
The formation and application of polymeric nanomaterials is great demandin science, industry, biotechnology, and medicine due to the possibility ofachieving a significant improvement in the physicochemical, mechanical,and barrier properties of polymers and using them as drug carriers andfillers, which is especially promising for biodegradable polymers such aschitosan and their derivatives. The article presents methods for creatingpolymer nanostructures based on polysaccharides and, in particular,chitosan. Obtaining nanostructured samples of chitosan using theapproaches of chemical transformation and modification of polysaccharidesis an urgent scientific problem, the solution of which makes it possible toobtain new polymer systems of great practical interest. The medical aspectsof the use of polymer carriers based on chitosan for the treatment of variousdiseases are discussed. The unique specificity of the properties of chitosanand nanomaterials derived from it, with the properties inherent in thisnatural polymer, can serve as a promising future, especially in the field ofmedicine.
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