新型给药策略:新概念

Patil Js
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引用次数: 6

摘要

现有药物分子的生物制药性能可以通过其从传统形式向新的递送系统的演变而得到显著改善。除了生物制药性能外,药物分子的安全性、有效性和患者依从性也得到了提高。当今的给药企业都非常重视多平台技术的开发,以获得竞争优势,扩大专利跨度,提高产品的市场占有率。在过去几年中,新型给药产品的数量显著增加,预计这种增长将在不久的将来继续。今天,由于基因组学领域的进步,大量公司忙于开发基于蛋白质和肽的药物分子,这反过来又加速了生物制药的研究。由于生物药物的独特性,很难通过传统的途径给药,这给给药科学家带来了挑战。因此,目前的研究重点是这些复杂分子如何通过口腔、鼻腔、肺部、阴道、直肠、口腔、结肠特异性等不同途径给药[1]。
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Novel Drug Delivery Strategies: New Concepts
The biopharmaceutical performance of an existing drug molecule can be significantly improved through its evolution from a conventional form to a novel delivery system. Apart from biopharmaceutical performances, the safety, efficacy and patient compliance are also improved for a drug molecule. Present day drug delivery companies are emphasizing prominently on development of multiple platform technologies for getting competitive merits, expand patent span, and enhance market share of their products. The quantum of novel drug delivery products has significantly increased in the past few years, and this growth is expected to continue in the near future. Today large numbers of companies are busy developing protein and peptide based drug molecules due to advancement in the field of genomics which in turn accelerated research of biopharmaceuticals. Due to the unique nature of biopharmaceuticals it is difficult to deliver them by conventional routes and this presents challenges to the drug delivery scientists. Therefore, present research is focusing on the delivery of these complex molecules through different routes including oral, nasal, pulmonary, vaginal, rectal, buccal, colon specific, etc. [1].
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