{"title":"HBs抗原应答的细胞介导免疫","authors":"Andrzej Szkaradkiewicz , Witold Kiczka","doi":"10.1016/S0340-904X(78)80048-7","DOIUrl":null,"url":null,"abstract":"<div><p>The response of peripheral blood leukocytes to purified HB<sub>s</sub>Ag was studied in vitro by means of the leukocyte migration test in patients with acute viral hepatitis B, patients with chronic aggressive hepatitis carrying HB<sub>s</sub>Ag, and in asymptomatic carriers of HB<sub>s</sub> antigen. In the acute period of the disease no leukocyte migration inhibition could be observed. Patients with chronic aggressive hepatitis also frequently failed to develop cell-mediated immunity to HB<sub>s</sub>Ag. Results obtained for HB<sub>s</sub> antigen carriers did not differ from those of normal blood donors. The observations may indicate participation of cell-mediated immunity in the development of liver damage.</p></div>","PeriodicalId":101288,"journal":{"name":"Zeitschrift für Immunit?tsforschung: Immunobiology","volume":"154 5","pages":"Pages 463-470"},"PeriodicalIF":0.0000,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0340-904X(78)80048-7","citationCount":"1","resultStr":"{\"title\":\"Cell-mediated Immunity in Response to HBs Antigen\",\"authors\":\"Andrzej Szkaradkiewicz , Witold Kiczka\",\"doi\":\"10.1016/S0340-904X(78)80048-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The response of peripheral blood leukocytes to purified HB<sub>s</sub>Ag was studied in vitro by means of the leukocyte migration test in patients with acute viral hepatitis B, patients with chronic aggressive hepatitis carrying HB<sub>s</sub>Ag, and in asymptomatic carriers of HB<sub>s</sub> antigen. In the acute period of the disease no leukocyte migration inhibition could be observed. Patients with chronic aggressive hepatitis also frequently failed to develop cell-mediated immunity to HB<sub>s</sub>Ag. Results obtained for HB<sub>s</sub> antigen carriers did not differ from those of normal blood donors. The observations may indicate participation of cell-mediated immunity in the development of liver damage.</p></div>\",\"PeriodicalId\":101288,\"journal\":{\"name\":\"Zeitschrift für Immunit?tsforschung: Immunobiology\",\"volume\":\"154 5\",\"pages\":\"Pages 463-470\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1978-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0340-904X(78)80048-7\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift für Immunit?tsforschung: Immunobiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0340904X78800487\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift für Immunit?tsforschung: Immunobiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0340904X78800487","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The response of peripheral blood leukocytes to purified HBsAg was studied in vitro by means of the leukocyte migration test in patients with acute viral hepatitis B, patients with chronic aggressive hepatitis carrying HBsAg, and in asymptomatic carriers of HBs antigen. In the acute period of the disease no leukocyte migration inhibition could be observed. Patients with chronic aggressive hepatitis also frequently failed to develop cell-mediated immunity to HBsAg. Results obtained for HBs antigen carriers did not differ from those of normal blood donors. The observations may indicate participation of cell-mediated immunity in the development of liver damage.
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