兔离体跳动心脏高空间分辨率局部脑卒中功测定

G. Gaudette, J. Todaro, E. Azeloglu, I. Krukenkamp, F. Chiang
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引用次数: 1

摘要

心脏跳动区域函数的确定需要一种高空间分辨率的局部形变测量技术。我们之前已经报道了计算机辅助散斑干涉测量(CASI)准确测定不跳动心脏变形的能力。在这里,我们使用这种技术来确定区域变形,从而确定区域左心室压力循环,也称为区域卒中工作。一个分离的兔子心脏被放置在一个改良的朗根多夫装置中,使左心室产生压力并向主动脉排出体积。CASI用于确定位于左心室前表面约4 × 6 mm区域的900多个点的同时变形。然后对心脏进行局部缺血,再次获得数据。从整个区域来看,局部缺血2分钟和5分钟时平均脑卒中功均下降,再灌注后部分恢复。并将该区域细分为24个区域,在每个区域确定区域脑卒中工作,得到与整个区域相似的结果。
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Determination of Regional Stroke Work With High Spatial Resolution in the Isolated Beating Rabbit Heart
The determination of regional function in the beating heart necessitates a technique to measure local deformation with high spatial resolution. We have previously reported the ability of computer aided speckle interferometry (CASI) to accurately determine deformation in the non-beating heart. Herein we use this technique to ascertain regional deformation allowing for the determination of regional area-left ventricular pressure loops, also known as regional stroke work. An isolated rabbit heart was placed in a modified Langendorff apparatus that allowed the left ventricle to develop pressure and eject volume into the aorta. CASI was used to determine the simultaneous deformation of over 900 points located in a region approximately 4 × 6 mm on the anterior surface of the left ventricle. The heart was then subjected to regional ischemia and data were again acquired. Over the whole region, the average regional stroke work decreased at both 2 and 5 minutes of regional ischemia, which partially recovered upon reperfusion. In addition, this region was subdivided into 24 areas, and regional stroke work was determined in each area and similar results to that obtained over the whole region were found.
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