外国医学生新型冠状病毒疫苗SARS-CoV-2 RNA检测频率

O. A. Ryabtseva, P. V. Tsygankov, S. Shlyk, G. G. Kharseeva, A. V. Chepusova
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The determination of SARS-CoV-2 RNA was carried out weekly from December 2021 to January 2022 by taking smears from the oropharynx and examining them using a test-PCR systems manufactured by the Federal State Budgetary Institution of the Central Research Institute of Epidemiology of Rospotrebnadzor «AmplisensCov-Bat-FL» (registration certificate No. RZN 2014/1987 dated 07.04.2020). Results. SARS-CoV-2 RNA was detected in 41 (8.0% [95% CI 5.6÷10.4]) of 510 international students surveyed. Among those vaccinated with vector vaccines based on human adenovirus (Sputnik V, Sputnik Light, Ad26. COV2.S (Johnson&Johnson)) SARS-CoV-2 RNA was detected in 27 (7.6% [95% CI 4.8÷10.4]) a person, mainly after 4–6 months. after vaccination; vaccines based on modified mRNA (BNT162b2 (Pfizer/BioNTech), mRNA1273 (Moderna)) – 5.7% [95% CI 1.1÷10.3] people within six months after vaccination. 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摘要

的相关性。在世界范围内,新型冠状病毒感染的发病率呈上升趋势。为了有效抗击COVID-19,有必要接种疫苗并控制SARS-CoV-2病毒株在人群中的传播,特别是从世界各地抵达俄罗斯的外国公民。的目标。目的测定境外医学生接种不同疫苗制剂后SARS-CoV-2 RNA的检出率。材料和方法。对2021年6 ~ 8月期间抵达俄罗斯的一所医科大学的18 ~ 25岁的外国留学生(510人)接种了新冠病毒疫苗进行了调查。从2021年12月至2022年1月,每周进行一次SARS-CoV-2 RNA的测定,方法是从口咽部提取涂片,并使用Rospotrebnadzor«AmplisensCov-Bat-FL»中央流行病学研究所联邦国家预算机构生产的检测- pcr系统进行检测(注册证书编号:RZN 2014/1987,日期为2020年4月7日)。结果。在接受调查的510名国际学生中,有41人(8.0% [95% CI 5.6÷10.4])检测到SARS-CoV-2 RNA。在接种了基于人腺病毒(Sputnik V, Sputnik Light, Ad26)的载体疫苗的人群中。COV2。在27人(7.6% [95% CI 4.8÷10.4])中检测到SARS-CoV-2 RNA,主要发生在4-6个月后。疫苗接种后;基于修饰mRNA的疫苗(BNT162b2(辉瑞/BioNTech), mRNA1273 (Moderna)) - 5.7% [95% CI 1.1÷10.3]接种后6个月内的人。39人的感染过程无症状,其中2人(接种了BNT162b2疫苗(辉瑞/ BioNTech)和Sputnik Light)有重度和中度的临床表现。结论。在接种新冠肺炎疫苗的留学生中,除2例外,还发现了SARS-CoV-2无症状携带者,这可能是潜在的感染源。这表明需要为外国和俄罗斯学生接种疫苗并及时重新接种疫苗,以及遵守防疫制度。
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Frequency of SARS-CoV-2 RNA Detection in Foreign Medical Students Vaccined against New Coronavirus Infection
Relevance. The incidence of the novel coronavirus infection is on the rise worldwide. To effectively combat COVID-19, both vaccination and control of the circulation of SARS-CoV-2 strains among the population and, especially, foreign citizens arriving in Russia from around the world are necessary. Aim. To determine the frequency of detection of SARS-CoV-2 RNA in foreign medical students vaccinated against COVID-19 with various vaccine preparations. Materials and methods. Foreign students (510 people) of a medical university aged 18-25 years, vaccinated against COVID-19, who arrived in Russia during June-August 2021, were examined. The determination of SARS-CoV-2 RNA was carried out weekly from December 2021 to January 2022 by taking smears from the oropharynx and examining them using a test-PCR systems manufactured by the Federal State Budgetary Institution of the Central Research Institute of Epidemiology of Rospotrebnadzor «AmplisensCov-Bat-FL» (registration certificate No. RZN 2014/1987 dated 07.04.2020). Results. SARS-CoV-2 RNA was detected in 41 (8.0% [95% CI 5.6÷10.4]) of 510 international students surveyed. Among those vaccinated with vector vaccines based on human adenovirus (Sputnik V, Sputnik Light, Ad26. COV2.S (Johnson&Johnson)) SARS-CoV-2 RNA was detected in 27 (7.6% [95% CI 4.8÷10.4]) a person, mainly after 4–6 months. after vaccination; vaccines based on modified mRNA (BNT162b2 (Pfizer/BioNTech), mRNA1273 (Moderna)) – 5.7% [95% CI 1.1÷10.3] people within six months after vaccination. The infectious process was asymptomatic in 39 people, in two (vaccinated with the BNT162b2 vaccine (Pfizer / BioNTech) and Sputnik Light) it had clinical manifestations of severe and moderate severity. Conclusion. Among foreign students vaccinated against COVID-19, in addition to two cases, asymptomatic carriers of SARS-CoV-2 have been identified, which may be a potential source of infection. This indicates the need for vaccination and timely revaccination of foreign and Russian students, as well as compliance with the anti-epidemic regime.
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