Substituent Effect on Pyridine Efficacy as a Chelating Stabilizer

Owing to the growing interest and unique properties of pyridines as bases, effects of sub - stitution and substituent modification on electron density enrichment of the pyridyl nitro gen, and thus the effectiveness of pyridine as metal ion-stabilizers will be introduced in this chapter. Pyridines of the structure C 5 (S)nH 5 -nN (S = substituent) that have been inten - sively studied theoretically were selected as examples to prove the concept of this chapter. Computational results in the reviewed reports showed that: substitution and substituent modification significantly affect the electronic enrichment of nitrogen atom of the pyridine. The conclusions extracted from the covered investigations were employed to promote pyri - dines to act as efficient stabilizers for the coordinated metal ions. In coordination chemistry, these kinds of coordinated complexes are highly demanded in the field of chemosensation.