{"title":"沉淀物分离方法对生物测定结果的影响","authors":"K. Ho, L. Mills, C. Mueller, S. Anderson, A. Malcolm","doi":"10.1002/TOX.2530090211","DOIUrl":null,"url":null,"abstract":"Four bioassays [MicrotoxTM, MutatoxTM, sister chromatid exchange (SCE), and metabolic cooperation] were used to analyze marine sediment extracts fractionated by two different methods: silica gel column chromatography and acid–base fractionation. Results indicated that a sediment extract fractionated with different methods can lead to different conclusions about the same sediment. \n \n \n \nThis research also further evaluated the new, mutagenic, bacterial bioassay Mutatox. Mutatox generally correlated with SCE and the Salmonella typhimurium assays. This rapid, operationally simple bioassay has potential as a screening bioassay to detect genotoxic agents. © 1994 by John Wiley & Sons, Inc..","PeriodicalId":11824,"journal":{"name":"Environmental Toxicology & Water Quality","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"20","resultStr":"{\"title\":\"The influence of sediment extract fractionation methods on bioassay results\",\"authors\":\"K. Ho, L. Mills, C. Mueller, S. Anderson, A. Malcolm\",\"doi\":\"10.1002/TOX.2530090211\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Four bioassays [MicrotoxTM, MutatoxTM, sister chromatid exchange (SCE), and metabolic cooperation] were used to analyze marine sediment extracts fractionated by two different methods: silica gel column chromatography and acid–base fractionation. Results indicated that a sediment extract fractionated with different methods can lead to different conclusions about the same sediment. \\n \\n \\n \\nThis research also further evaluated the new, mutagenic, bacterial bioassay Mutatox. Mutatox generally correlated with SCE and the Salmonella typhimurium assays. This rapid, operationally simple bioassay has potential as a screening bioassay to detect genotoxic agents. © 1994 by John Wiley & Sons, Inc..\",\"PeriodicalId\":11824,\"journal\":{\"name\":\"Environmental Toxicology & Water Quality\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"20\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Environmental Toxicology & Water Quality\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/TOX.2530090211\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Toxicology & Water Quality","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/TOX.2530090211","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 20
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