{"title":"足球草根水提物对四氧嘧啶诱导的糖尿病大鼠的抗糖尿病活性","authors":"M. Yakubu, M. Akanji, M. O. Nafiu","doi":"10.4314/CAJEB.V6I2.68526","DOIUrl":null,"url":null,"abstract":"Aqueous extract of Cochlospermum planchonii root was investigated for antidiabetic activity in alloxan-induced diabetic rats. Thirty albino rats (110.33 ± 8.69 g) were randomized into six groups (A-F) such that group A (non-diabetic) received orally 0.5 ml of distilled water, thrice daily for 10 days. Animals in groups B, C, D, E and F which were all made diabetic with alloxan (150 mg/kg b. w., i.p.) also received 0.5 ml of glibenclamide (2.5 mg/kg b. w., p.o.), 25, 50 and 100 mg/kg b. w., p.o. of the extract respectively. The blood glucose of the alloxanized rats after 48 hours which ranged from 20.50-30.20 mmol/L were significantly (P Cochlospermum planchonii root possesses anti-hyperglycemic activity similar to the reference drug. The extract of Cochlospermum planchonii root is also effective in controlling some of the disorders of metabolism associated with diabetes. Keywords: Alloxan, Cochlospermaceae, Cochlospermum planchonii, Diabetes, Metabolic disorders, Glibenclamide","PeriodicalId":9401,"journal":{"name":"Cameroon Journal of Experimental Biology","volume":"88 1","pages":"91-100"},"PeriodicalIF":0.0000,"publicationDate":"2011-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"24","resultStr":"{\"title\":\"Anti-diabetic activity of aqueous extract of Cochlospermum planchonii root in alloxan-induced diabetic rats\",\"authors\":\"M. Yakubu, M. Akanji, M. O. Nafiu\",\"doi\":\"10.4314/CAJEB.V6I2.68526\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aqueous extract of Cochlospermum planchonii root was investigated for antidiabetic activity in alloxan-induced diabetic rats. Thirty albino rats (110.33 ± 8.69 g) were randomized into six groups (A-F) such that group A (non-diabetic) received orally 0.5 ml of distilled water, thrice daily for 10 days. Animals in groups B, C, D, E and F which were all made diabetic with alloxan (150 mg/kg b. w., i.p.) also received 0.5 ml of glibenclamide (2.5 mg/kg b. w., p.o.), 25, 50 and 100 mg/kg b. w., p.o. of the extract respectively. The blood glucose of the alloxanized rats after 48 hours which ranged from 20.50-30.20 mmol/L were significantly (P Cochlospermum planchonii root possesses anti-hyperglycemic activity similar to the reference drug. The extract of Cochlospermum planchonii root is also effective in controlling some of the disorders of metabolism associated with diabetes. Keywords: Alloxan, Cochlospermaceae, Cochlospermum planchonii, Diabetes, Metabolic disorders, Glibenclamide\",\"PeriodicalId\":9401,\"journal\":{\"name\":\"Cameroon Journal of Experimental Biology\",\"volume\":\"88 1\",\"pages\":\"91-100\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-08-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"24\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cameroon Journal of Experimental Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/CAJEB.V6I2.68526\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cameroon Journal of Experimental Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/CAJEB.V6I2.68526","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Anti-diabetic activity of aqueous extract of Cochlospermum planchonii root in alloxan-induced diabetic rats
Aqueous extract of Cochlospermum planchonii root was investigated for antidiabetic activity in alloxan-induced diabetic rats. Thirty albino rats (110.33 ± 8.69 g) were randomized into six groups (A-F) such that group A (non-diabetic) received orally 0.5 ml of distilled water, thrice daily for 10 days. Animals in groups B, C, D, E and F which were all made diabetic with alloxan (150 mg/kg b. w., i.p.) also received 0.5 ml of glibenclamide (2.5 mg/kg b. w., p.o.), 25, 50 and 100 mg/kg b. w., p.o. of the extract respectively. The blood glucose of the alloxanized rats after 48 hours which ranged from 20.50-30.20 mmol/L were significantly (P Cochlospermum planchonii root possesses anti-hyperglycemic activity similar to the reference drug. The extract of Cochlospermum planchonii root is also effective in controlling some of the disorders of metabolism associated with diabetes. Keywords: Alloxan, Cochlospermaceae, Cochlospermum planchonii, Diabetes, Metabolic disorders, Glibenclamide