H. Endo, Yoshiteru Watanabe, M. Matsumoto, Shoichi Shirotake
{"title":"热敏熔融凝胶的制备与评价","authors":"H. Endo, Yoshiteru Watanabe, M. Matsumoto, Shoichi Shirotake","doi":"10.5649/JJPHCS1975.26.250","DOIUrl":null,"url":null,"abstract":"The aim of the present study was to prepare a heat-sensitive melting gel using κ-carrageenan and gelatin as the gelation agents. The two agents have similar melting points (40-50°C for κ-carrageenan and 20-30°C for gelatin). When mixed together, they have a coexisting grid structure, which is favorable for the preparation of a gel with a melting temperature close to the human body temperature. Gel preparation showed a clearly different melting behavior from that of many other compounds and began to soften significantly below its melting temperature.κ-carrageenan at 0.5% may thus be the preferred concentration because preparations having a melting temperature just below the human body temperature are easy to chew, with a rapidly decreasing viscosity. We studied the plasma concentrations of acetaminophen as a function of time after the oral administration of a bulk powder or gel preparation of acetaminophen to rabbits after overnight fasting. A comparison of the AUC for both oral and intravenous administration indicated the bioavailability of acetaminophen gel to be about 90%. The heat-sensitive acetaminophen melting gel prepared using κ-carrageenan and gelatin thus shows promise for clinical use because of its favorable physicochemical and pharmaceutical characteristics.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"9 1","pages":"250-258"},"PeriodicalIF":0.0000,"publicationDate":"2000-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"Preparation and Evaluation of Heat-sensitive Melting Gel\",\"authors\":\"H. Endo, Yoshiteru Watanabe, M. Matsumoto, Shoichi Shirotake\",\"doi\":\"10.5649/JJPHCS1975.26.250\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aim of the present study was to prepare a heat-sensitive melting gel using κ-carrageenan and gelatin as the gelation agents. The two agents have similar melting points (40-50°C for κ-carrageenan and 20-30°C for gelatin). When mixed together, they have a coexisting grid structure, which is favorable for the preparation of a gel with a melting temperature close to the human body temperature. Gel preparation showed a clearly different melting behavior from that of many other compounds and began to soften significantly below its melting temperature.κ-carrageenan at 0.5% may thus be the preferred concentration because preparations having a melting temperature just below the human body temperature are easy to chew, with a rapidly decreasing viscosity. We studied the plasma concentrations of acetaminophen as a function of time after the oral administration of a bulk powder or gel preparation of acetaminophen to rabbits after overnight fasting. A comparison of the AUC for both oral and intravenous administration indicated the bioavailability of acetaminophen gel to be about 90%. The heat-sensitive acetaminophen melting gel prepared using κ-carrageenan and gelatin thus shows promise for clinical use because of its favorable physicochemical and pharmaceutical characteristics.\",\"PeriodicalId\":14621,\"journal\":{\"name\":\"Japanese Journal of Hospital Pharmacy\",\"volume\":\"9 1\",\"pages\":\"250-258\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-06-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Japanese Journal of Hospital Pharmacy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5649/JJPHCS1975.26.250\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese Journal of Hospital Pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5649/JJPHCS1975.26.250","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Preparation and Evaluation of Heat-sensitive Melting Gel
The aim of the present study was to prepare a heat-sensitive melting gel using κ-carrageenan and gelatin as the gelation agents. The two agents have similar melting points (40-50°C for κ-carrageenan and 20-30°C for gelatin). When mixed together, they have a coexisting grid structure, which is favorable for the preparation of a gel with a melting temperature close to the human body temperature. Gel preparation showed a clearly different melting behavior from that of many other compounds and began to soften significantly below its melting temperature.κ-carrageenan at 0.5% may thus be the preferred concentration because preparations having a melting temperature just below the human body temperature are easy to chew, with a rapidly decreasing viscosity. We studied the plasma concentrations of acetaminophen as a function of time after the oral administration of a bulk powder or gel preparation of acetaminophen to rabbits after overnight fasting. A comparison of the AUC for both oral and intravenous administration indicated the bioavailability of acetaminophen gel to be about 90%. The heat-sensitive acetaminophen melting gel prepared using κ-carrageenan and gelatin thus shows promise for clinical use because of its favorable physicochemical and pharmaceutical characteristics.