微颗粒制剂作为靶向给药系统

A. Abdellatif
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引用次数: 5

摘要

理想的缓释产品不仅应具有延长药物释放的功能,而且应提供一天1次或2次的剂量治疗和较好的治疗药物水平控制;这将有两个好处:第一是减少副作用,第二是改善疾病管理。因此,由于减少了每日给药的频率,患者的依从性很好[1,2]。患者依从性问题及其对药物治疗的巨大影响是考虑到药物吸收及其药代动力学的巨大进步和广泛的研究工作,聚合物技术的快速发展和其他一些因素是长期作用剂型的兴趣和基本原理设计的背后[3]。缓释或控释药物分为三种基本类型:(1)缓释剂型,(2)缓释剂型,(3)重复作用剂型[4]。
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Microparticles Formulation as a Targeting Drug Delivery System
The ideal sustained release products should not only have a prolonged drug releasing function, but should also offer once or twice a day dose treatment and better control of therapeutic drug level; this will have two benefits: the first is fewer side effects and the second is improved disease management. Hence a good patient compliance is obtained due to reduction in the frequency of daily dosing [1,2]. The problem of patient compliance and its considerable effect on drug therapy is the great advances and extensive research work considering drug absorption and its pharmacokinetics, the rapid growth of polymer technology and some other factors are behind the interest and rationale design of prolonged action dosage forms [3]. Prolonged or controlled release drugs are classified into three basic types: (1) Sustained release, (2) Prolonged action, and (3) repeat action dosage forms [4].
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