甲氧苄啶-磺胺甲恶唑(TMP-SMX)是治疗儿童社区获得性耐甲氧西林金黄色葡萄球菌感染的一种选择吗?

Rosanova Mt, R. Lede
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引用次数: 0

摘要

虽然我们没有根据感染的位置和严重程度排除研究,但没有发现使用TMP-SMX治疗侵袭性感染的研究符合高级别证据。所有纳入的研究都集中在皮肤和软组织感染上,这是最常见的ca - mrsa相关感染。在其他感染中,TMP-SMX的作用尚未明确界定。由于担心治疗失败,它在治疗侵袭性感染方面的应用一直不被鼓励。
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Is Trimethoprim-Sulfamethoxazole (TMP-SMX) An Alternative in the Management of Infections by Community-Acquired Methicillin Resistant Staphylococcus aureus in Children?
Although we did not exclude studies according to the location and severity of infections, no studies on invasive infections treated with TMP-SMX that met high grade of evidence was found. All the studies included were focused on skin and soft-tissue infections, which are the most common CA-MRSA-related infections. In other infections the role of TMP-SMX is not clearly defined. Its use in the treatment of invasive infections has been discouraged because of a concern for therapeutic failures.
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