Efficacy of intra-articular methylprednisolone along with platelet rich plasma vs. platelet rich plasma in early osteoarthritis: a retrospective study

Background: Increased prevalence as well as burden affecting osteoarthritis of knee joint has led to increase in concerns regarding safety of various pharmacological methods. Hence, there is an increase in demand for newer and effective strategies for treatment and manage­ment. Thus, a novel alternate for treatment is required that might repair damage to cartilage rather than simply reduce related symptoms. The aim of this study was to study the efficacy of intra-articular methylprednisolone along with platelet rich plasma versus platelet rich plasma in early knee osteoarthritis. Methods: This retrospective study was conducted on 60 patients diagnosed with initial stages of osteoarthritis of knee according to Kellgren-Lawrence classification. Patients age range was between 40 to 80 years who were divided into 2 groups; group I: It contained 30 subjects treated with intra-articular injections of Platelet Rich Plasma in combination with methylprednisolone and group II: comprised of 30 patients treated with intra-articular injection of Platelet rich Plasma alone. Clinical data pertaining to medical history, VAS and KOOS scores were collected. Statistical analysis was performed using the student’s t test. Results: Statistically significant improvements in VAS and KOOS score values were observed on assessment of scores at baseline, 1, 3 and 6 months intervals, respectively. Conclusions: It can be concluded from the study that a combination therapy of intra-articular injection of combination of PRP with methylprednisolone yields superior results when compared to use of PRP injections alone.