营养在乳腺癌治疗中的作用综述

S. K, S. S.
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引用次数: 0

摘要

乳腺癌(BC)是女性中最常见的恶性肿瘤,也是全球第二大常见癌症原因。有很多证据表明,包括食物、体重和体育活动在内的生活方式因素与患乳腺癌的高风险有关。几种生物活性食品成分,包括必需和非必需营养素,可以改变基因表达谱。因此,营养基因组学提供了关于所消耗的营养素和其他食物成分对基因调控和转录因子的影响的信息,即饮食-基因相互作用,以发现对健康有益或有害的饮食成分。生物过程,如表观遗传学,转录组学和蛋白质组学影响营养基因组学(营养基因组学),这是健康,食品和基因组学的交界处。因此,它将有助于根据一个人的基因组成(个性化饮食)确定独特的营养需求,也有助于确定饮食与癌症等慢性疾病之间的联系,为更好地了解乳腺癌的影响及其管理开辟新的途径。化疗或放疗的BC患者会经历各种影响其生活质量的症状。根据对BC治疗期间营养治疗的研究,营养咨询和补充一定的膳食元素可能有助于减少药物引起的副作用,提高治疗效果。因此,对BC患者的营养控制可能被认为是多模式治疗策略的关键组成部分。本综述的目的是对饮食变量与BC之间关系的现有研究进行总结。
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A Comprehensive Review on Role of Nutrition in Management of Breast Cancer
Breast cancer (BC) is the most frequent malignancy in women and the second most common cause of cancer worldwide. There’s a lot of evidence that lifestyle factors including food, body weight, and physical activity are linked to a higher risk of breast cancer. Several bioactive food ingredients, including both essential and non-essential nutrients, can change gene expression profiles. Consequently, nutrigenomics provides information on the effects of consumed nutrients and other food components on gene regulation and transcription factors, i.e., diet-gene interaction, to find dietetic components that are beneficial or damaging to one’s health. Biological processes such as epigenetics, transcriptomics, and proteomics influence nutritional genomics (nutrigenomics), which is the junction of health, food, and genomics. As a result, it will help to determine unique nutritional requirements based on a person’s genetic composition (personalized diet), and also the link between diet and chronic diseases such as cancer, opening up new avenues for a better understanding of the impacts of breast cancer and its management. Chemotherapy or radiotherapy patients with BC experience a variety of symptoms that influence their quality of life. According to research studies on nutritional therapy during BC treatment, nutritional counseling and supplementation with certain dietary elements may be useful in reducing drug-induced side effects and increasing therapeutic efficacy. As a result, nutritional control in BC patients may be considered a critical component of a multimodal treatment strategy. The goal of this review is to give a summary of the existing research on the association between dietary variables and BC.
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