实时NIR-IIb荧光成像引导乳腺癌精准手术的肿瘤靶向稀土纳米晶体制备

IF 4.2 2区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2022-07-01 DOI:10.1016/j.nano.2022.102555
Kang-Liang Lou BA , Pei-Yuan Wang PhD , Rui-Qin Yang MA , Yi-Yang Gao MA , Hai-Na Tian MA , Yong-Ying Dang BA , Yang Li PhD , Wen-He Huang BA , Min Chen PhD , Xiao-Long Liu PhD , Guo-Jun Zhang MD, PhD
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引用次数: 6

摘要

近红外荧光成像已被纳入手术室指导肿瘤切除,可能降低保乳手术(BCS)的阳性切缘率。相对于广泛使用的第一近红外荧光成像,第二近红外(NIR-II)区成像具有更高的对比度和更深的组织穿透,特别是在NIR-IIb窗口,为成像引导的BCS提供了许多新的机会。在这里,我们制备了c(RGDfC)功能化的铒基稀土纳米粒子(ErNPs@cRGD),在NIR-IIb区具有优异的光学性能。ErNPs@cRGD-based NIR-IIb荧光成像由于具有更深的组织穿透性和高效的肿瘤靶向性,在肿瘤可视化中实现了更高的信本比,在各种小鼠模型中能够指导更完整的肿瘤切除,识别多发微肿瘤,区分恶性病变与正常组织。在此基础上,采用NIR-IIb影像策略进行手术导航,可显著降低阳性切缘率,改善预后,为乳腺癌临床切除奠定基础。
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Fabrication of tumor targeting rare-earth nanocrystals for real-time NIR-IIb fluorescence imaging-guided breast cancer precise surgery

The near-infrared fluorescence imaging has been integrated into the operating room to guide tumor resection, potentially reducing the positive margin rates in breast-conserving surgery (BCS). Relative to the widely used first near-infrared fluorescence imaging, imaging in the second near-infrared (NIR-II) region possesses higher contrast and deeper tissue penetration, particularly in the NIR-IIb window, offering many new opportunities for imaging-guided BCS. Here, we fabricated the c(RGDfC) functionalized erbium-based rare-earth nanoparticles (ErNPs@cRGD) with superior optical property in NIR-IIb region. Owing to deeper tissue penetration and efficient tumor targeting, ErNPs@cRGD-based NIR-IIb fluorescence imaging achieved enhanced signal-to-background ratios in tumor visualization, which was able to guide more complete tumor resection, identify multiple microtumors and distinguish malignant lesions from normal tissues in various mice models. Based on these, this NIR-IIb imaging strategy for surgical navigation can significantly reduce positive margin rates and improve prognosis, laying a foundation for the clinical resection of breast cancer.

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来源期刊
CiteScore
11.10
自引率
0.00%
发文量
133
审稿时长
42 days
期刊介绍: The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine. Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.
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