运动复合物形成微管的动力学

François Nédélec, Thomas Surrey
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引用次数: 29

摘要

纤维的聚合和运动蛋白的移动有助于高级细胞的细胞骨架的组织。这些元素的混合物能做什么,目前还不清楚。利用计算机模拟,我们在一个简单的系统中研究了由马达和微管生长形成紫菀的动力学。我们发现系统可以在三种不同的制度取决于微管聚合率的值。我们讨论了网络中存在的三种类型的运动链接,并展示了它们如何促成每种最终模式。
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Dynamics of microtubule aster formation by motor complexes

The polymerisation of filaments and their moving by motor proteins contribute to the organisation of the cytoskeleton of higher cells. What a mixture of such elements is capable of doing, is not yet understood. Using computer simulations, we study here in a simple system the kinetics of aster formation by motors and growing microtubules. We find that the system can be in three different regimes depending on the value of the microtubule polymerisation rate. We discuss that three types of motor links are present in the network and show how they contribute to each final pattern.

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