运动对2型糖尿病患者冠状动脉血流储备及生化指标的影响

Göksel Güz, H. Oflaz
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摘要

糖尿病患者最主要的死亡和发病原因是冠状动脉、外周和脑部疾病。我们的研究目的是在没有缺血性症状的情况下,通过经胸超声心动图测量冠状动脉血流储备,无创地确定2型糖尿病患者心外膜冠状动脉和微血管循环的功能障碍,并证明在8周的常规运动后,内皮功能、血糖控制和胰岛素抵抗的改善以及冠状动脉血流储备的增加。本研究选取伊斯坦布尔医学院糖尿病学系诊断为2型糖尿病的40例无缺血性症状的糖尿病患者和20例健康受试者,随访3年以上。将参加锻炼计划的糖尿病患者运动前的基础值与不定期锻炼的糖尿病患者的基础值进行比较。总之,有规律的运动和身体活动对糖尿病患者预防心血管事件的一级和二级保护非常重要。体育活动增加糖尿病患者的胰岛素敏感性,对葡萄糖代谢有许多积极作用。这是减少肥胖和内脏脂肪组织的重要途径。有证据指出,有规律的运动可以延缓甚至预防糖尿病的发生。
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Effects of Exercise On Coronary Flow Reserve And Biochemical Parameters in Patients With Type 2 Diabetes Mellitus
The most important mortality and morbidity causes in diabetic patients are coronary, peripheral and cerebral diseases. The aim of our study was to noninvasively determine dysfunction in epicardial coronary arteries and microvascular circulation with measurement of coronary flow reserve using transthoracic echocardiography in patients with type 2 diabetes despite absence of ischemic symptoms, and to demonstrate the amelioration in endothelial functions, glycemic control and insulin resistance along with increase in coronary flow reserve after 8 weeks of regular exercise. 40 patients diagnosed with type 2 diabetes in Istanbul Facuty of Medicine, Department of Diabetes, who were on follow-up for at least three years due to diabetes, without ischemic symptoms and 20 healthy subjects took part in study. Basal values before exercise of diabetic patients who were included in the exercise program were compared with basal values of diabetic patients who did not exercise regularly. To summarize, regular exercise and physical activity are highly important in diabetic patients for primary and secondary protection against cardiovascular incidents. Physical activity increases insulin sensitivity in diabetic patients, and has many positive effects on glucose metabolism. It is the important way to decrease obesity and visceral fat tissue. There is evidence pointing out that regular exercise can defer or even prevent initiation of diabetes.
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