Angelina A. Kutina, E. G. Sumina, N. Yurasov, V. Z. Uglanova
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Determination of statins by reverse-phase HPLC in mobile phases with different modification options
The chromatographic behavior of atorvastatin, rosuvastatin and simvastatin in the presence of the main modifiers of the mobile phase: elution strength and buffer solution, has been studied by means of the reverse-phase high-performance liquid chromatography (HPLC) method. Optimal modification conditions have been found and their application for the determination of statins under study in the pharmaceutical preparations Atorvastatin-OBL, Liprimar and Tulip has been shown. The Sr value is 0.03. The relative determination error does not exceed 7%.
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