肿瘤坏死因子(TNF)- α和TNF受体在病毒发病中的作用。

Georges Herbein, William A. O'Brien
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引用次数: 201

摘要

肿瘤坏死因子- α (TNF- α)和TNF受体(TNFR)是生长中的TNF配体和受体家族的成员,参与免疫调节。本报告将重点关注原型配体TNF及其两种受体TNFR1和TNFR2在病毒发病机制中的作用。尽管多年前就有TNF调节病毒感染的报道,但最近关于TNF信号通路的发现使人们更好地了解了感染细胞内细胞因子和病毒因子之间的分子相互作用。病毒蛋白与TNFR下游细胞内成分的相互作用在分子水平上突出了病毒如何操纵细胞机制以逃避免疫反应并有利于感染的传播。我们将在此综述TNF和TNFR在免疫应答中的作用以及TNF和TNFR信号在病毒发病机制中的作用。
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Tumor necrosis factor (TNF)-alpha and TNF receptors in viral pathogenesis.
Tumor necrosis factor-alpha (TNF-alpha) and TNF receptors (TNFR) are members of the growing TNF ligand and receptor families that are involved in immune regulation. The present report will focus on the role of the prototypic ligand TNF and its two receptors, TNFR1 and TNFR2, in viral pathogenesis. Although TNF was reported years ago to modulate viral infections, recent findings on the molecular pathways involved in TNFR signaling have allowed a better understanding of the molecular interactions between cellular and viral factors within the infected cell. The interactions of viral proteins with intracellular components downstream of the TNFR have highlighted at the molecular level how viruses can manipulate the cellular machinery to escape the immune response and to favor the spread of the infection. We will review here the role of TNF and TNFR in immune response and the role of TNF and TNFR signaling in viral pathogenesis.
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